ArticleFrontiers in endocrinology2026
Pregnancy outcomes after fresh and frozen embryo transfer in women of advanced age and analysis of influencing factors: single-center experience.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the differences in pregnancy outcomes between fresh embryo transfer (ET) and frozen embryo transfer (FET) in women of advanced age undergoing assisted reproductive technology (ART), and to provide evidence for optimizing embryo transfer strategies. Methods: This retrospective study included 359 women of advanced age (35-45 years) who underwent fresh ET and 605 who underwent FET at the Department of Reproductive Medicine, Lianyungang Maternal and Child Health Hospital from January 2019 to April 2025. Following 1:1 propensity score matching, 288 fresh ET and 288 FET cycles were analyzed. Clinical pregnancy rate, miscarriage rate, live birth rate, preterm birth rate, and neonatal birth weight were compared between the two groups. Multivariable logistic regression was used to identify factors associated with live birth, and conditional logistic regression was performed. Results: In the matched cohort, miscarriage rate and preterm birth rate were comparable between two groups (both Conclusion: In women of advanced age, the transfer strategy was not an independent predictor of live birth. Instead, younger maternal age and transfer of two embryos were the key factors to improved live birth outcomes.
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