ArticleNature and science of sleep2026
Medication Treatment Modulates Sleep Architecture and Cognitive-Related Cortical Hemodynamics in Narcolepsy Type 1.
Article in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This exploratory pilot study aimed to evaluate the associations between combination medication treatment and changes in sleep architecture and cognitive task-related cortical hemodynamics in narcolepsy type 1 (NT1). Methods: A total of 16 drug-naive NT1 patients were enrolled. All participants underwent polysomnography (PSG), multiple sleep latency test (MSLT), and fNIRS monitoring during Verbal Fluency Test (VFT) and Go/NoGo task before and after pharmacological intervention. Paired nonparametric tests were used to compare differences in PSG, MSLT, and fNIRS parameters before and after treatment. Least absolute shrinkage and selection operator (LASSO) regression and stepwise regression were applied to screen predictors of sleep latency. Results: REM latency and mean sleep latency from MSLT were significantly prolonged, and REM sleep proportion was significantly reduced after medication treatment. During VFT, significant changes in oxyhemoglobin (HbO Conclusion: In this pilot cohort, combination medication therapy was associated with prolongation of sleep latency and task-specific alterations in cortical hemodynamics in NT1 patients. fNIRS-derived parameters show preliminary potential as non-invasive biomarkers for predicting post-treatment sleep latency, which requires validation in larger independent cohorts.
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