Evidence map›Paper›PMID 42656185›Full record

ReviewAnalytical cellular pathology (Amsterdam)2026

Deployment of Artificial Intelligence in Clinical Oral Pathology: Evidence Summary and Implementation Gaps.

J H Shazia Fathima, Mugundan Raghavelu Narendran, Mohammed Sharique Ahmed Quadri, Thilla Sekar Vinothkumar, K A Kamala, Mohmed Isaqali Karobari

Abstract readReview
In one paragraph

Review in Analytical cellular pathology (Amsterdam), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J H Shazia FathimaGlobal Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune 411018, India, dpu.edu.in.ORCID https://orcid.org/0000-0002-5200-5888
Mugundan Raghavelu NarendranDepartment of Oral Pathology and Microbiology, Ragas Dental College and Hospital, ECR Uthandi, Chennai 600119, Tamil Nadu, India.ORCID https://orcid.org/0000-0003-1991-2619
Mohammed Sharique Ahmed QuadriDepartment of Basic Medical Sciences, College of Medicine, Almaarefa University, Dariyah, Riyadh 13713, Saudi Arabia, um.edu.sa.ORCID https://orcid.org/0009-0007-1781-0236
Thilla Sekar VinothkumarDepartment of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia, jazanu.edu.sa.ORCID https://orcid.org/0000-0001-9798-3872
K A KamalaDepartment of Oral Medicine and Radiology, School of Dental Sciences, KVVDU, Satara, Karad 415110, Maharashtra, India.ORCID https://orcid.org/0000-0003-4426-9995
Mohmed Isaqali KarobariDepartment of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India, saveetha.com.ORCID https://orcid.org/0000-0002-0313-9695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhole-slide imaging (WSI) has shifted pathology toward digital workflows, creating the foundation for applying artificial intelligence (AI) to diagnostic tasks. This review summarises validated AI applications in diagnostic pathology, with an emphasis on clinical performance, regulatory developments and the practical barriers that affect implementation.

methodsA structured search of PubMed, Scopus and Google Scholar identified English-language, peer-reviewed studies from January 2020 to May 2025. Eligible studies applied AI to diagnostic, grading or prognostic tasks in human tissue, used a pathologist-confirmed reference standard and included external or multi-centre validation.

resultsMore than 150,000 digital slides were represented across the included studies. Reported performance metrics demonstrated strong diagnostic accuracy across several validated applications. Large meta-analyses and externally validated studies reported sensitivity values exceeding 96% and specificity above 93% for selected cancer-detection tasks, while other studies demonstrated high agreement for Gleason grading (QWK up to 0.862) and biomarker quantification (Ki-67 ICC 0.98).

conclusionAI has the capacity to strengthen diagnostic pathology by improving consistency, measurement and efficiency. Moving from experimental use to routine reporting will require broad validation across centres, enhanced model transparency, strong quality-assurance systems and close cooperation between developers and pathologists.

Indexed as

Artificial IntelligencePathology, OralHumansartificial intelligencediagnostic accuracydigital pathologyimplementationregulatory sciencevalidationwhole-slide imaging

Identifiers

PMID42656185
PMCPMC13519655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.