ArticleSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2026
[Noninvasive nanosecond transcranial pulsed electric fields: deep-penetrating, high-field stimulation for suppressing hippocampal amyloid-β and improving cognitive function in an Alzheimer's disease model].
Article in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Abnormal deposition of amyloid-β (Aβ) in the deep-brain hippocampus can impair synaptic transmission and disrupt neural network activity, thereby inducing learning and memory deficits and accelerating cognitive decline in Alzheimer's disease (AD). Therefore, reducing hippocampal Aβ deposition is an important strategy for delaying AD progression. Existing transcranial electrical stimulation methods are limited by safety thresholds and are difficult to achieve effective field strength in deep brain regions under noninvasive conditions, thus failing to effectively intervene in hippocampal Aβ deposition. Nanosecond pulsed electric fields, which contain abundant high-frequency components and exhibit stronger transcranial penetration capability, may overcome this limitation. In this study, nanosecond transcranial pulsed electric field stimulation (ns-tPFS) was applied with parameters of 500 ns band width, 500 V amplitude, and 5 Hz frequency in a five familial AD mutations (5xFAD) mouse model. First, finite element simulation was performed to determine that the electric field strength generated by ns-tPFS in the hippocampal region could reach 3 × 10
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