Evidence map›Paper›PMID 42656011›Full record

ArticleEuropean journal of neurology2026

Shared Spectral Parameters Between EEG and Basal Ganglia LFP Distinguish Sleep-Specific Oscillations in Parkinson's Disease.

Lisa Hirt, Ruby Martini, Siqun Tang, Michael Summers, Lesile West, Clete Kushida, Stephen V Gliske, Dulce Maroni, Younghoon Nho, Casey H Halpern and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04620551 (Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04620551 nacompletednot on this map

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and Repair

TypeinterventionalSponsorUniversity of NebraskaRan2020 to 2026Enrolled20ConditionsParkinson Disease, Sleep FragmentationArmsSub-clinical stimulation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lisa HirtDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-3393-7938
Ruby MartiniDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0009-0005-1393-4501
Siqun TangSleep Medicine Division, Department of Psychiatry and Behavioral Science, Stanford University, Stanford, California, USA.
Michael SummersNebraska Medicine Sleep Center, Division of Pulmonary, Critical Care & Sleep Medicine, Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Lesile WestDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Clete KushidaSleep Medicine Division, Department of Psychiatry and Behavioral Science, Stanford University, Stanford, California, USA.
Stephen V GliskeDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-2259-2612
Dulce MaroniDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Younghoon NhoRichards Medical Research Laboratories, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Casey H HalpernRichards Medical Research Laboratories, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3907-216X
Aviva AboschMiami Neuroscience Institute at Baptist Hospital, Miami, Florida, USA.ORCID https://orcid.org/0000-0001-7012-4875
John A ThompsonDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0003-2991-5194

Funding

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and RepairUH3NS113769 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ABOSCH, AVIVA, HALPERN, CASEY HARRISON · 2020 to 2025
$5.2M
NINDS NIH HHS UH3 NS113769
6 · The paper itself

Abstract

backgroundIn Parkinson's disease (PD), sleep-related oscillatory dynamics between basal ganglia and cortical nodes may inform sleep dysfunction. The subthalamic nucleus (STN) is highly interconnected with human sleep circuitry and is a current target of interest for sleep neuromodulation.

methodsTo investigate correlated cortical-subcortical activity, we recorded simultaneous PSG and STN local field potentials (LFP) in 19 patients undergoing deep brain stimulation (DBS) for PD. We evaluated the correlation in spectral power between STN-LFP and EEG during polysomnogram (PSG)-defined stages of sleep. In addition, we analyzed aperiodic 1/f spectral parameters (exponent and offset), which have been identified as markers of arousal across sleep stages. Finally, we trained classifiers on aperiodic features to test whether 1/f structure alone could recover PSG-defined sleep stages from EEG and STN-LFP.

resultsResults revealed a significant interaction between recording modality and sleep stage. During wakefulness and REM sleep, STN-LFP exhibited a significantly steeper spectral slope compared to scalp EEG. However, this dissociation diminished with sleep depth; slopes appeared more similar during N2 and reversed during N3, where EEG became steeper than LFP. Across subjects, the aperiodic component showed robust state dependence and modality differences with STN-LFP maintaining higher exponents overall. STN-LFP aperiodic features alone classified sleep stages above chance and outperformed scalp EEG, approaching the combined-modality ceiling.

conclusionThese findings highlight distinct subcortical electrophysiological signatures in sleep-dependent regulation of neural arousal across brain networks in PD. These insights offer potential biomarkers for both invasive and non-invasive forms of closed-loop neuromodulation strategies targeting sleep dysfunction.

trial registrationClinicalTrials.gov identifier: NCT04620551.

Indexed as

Basal GangliaElectroencephalographyParkinson DiseaseSleepSleep StagesSubthalamic NucleusAgedDeep Brain StimulationFemaleHumansLocal Field Potential MeasurementMaleMiddle AgedPolysomnographybasal ganglialocal field potentialParkinson's diseasepolysomnographysleep dysfunction

Identifiers

PMID42656011
PMCPMC13519526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.