Evidence map›Paper›PMID 42655851›Full record

ReviewVeterinary sciences2026

Probiotics in Poultry: A Comprehensive Review of Mechanisms, Applications, and Future Directions.

Zhe Jia, Yanfei He, Haijun Xu, Cai Zhang, Shunan Cuan

Abstract readReview
In one paragraph

Review in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhe JiaCollege of Life and Health, West Anhui University, Lu'an 237012, China.
Yanfei HeCollege of Life and Health, West Anhui University, Lu'an 237012, China.
Haijun XuCollege of Life and Health, West Anhui University, Lu'an 237012, China.
Cai ZhangHenan International Joint Laboratory of Animal Welfare and Health Breeding, Henan University of Science and Technology, Luoyang 471023, China.ORCID 0000-0002-0918-6601
Shunan CuanCollege of Life and Health, West Anhui University, Lu'an 237012, China.ORCID 0009-0001-5350-6406

Funding

National Natural Science Foundation of China 32402937West Anhui University WXZR202508West Anhui University XDGJ202504
6 · The paper itself

Abstract

Global poultry consumption continues to rise, while worldwide bans on in-feed antibiotic growth promoters raise an urgent requirement for eco-friendly alternatives to guarantee production efficiency and food safety. Probiotics, live beneficial microorganisms that improve host intestinal health, are reviewed. We elaborate four core functional pathways of probiotics: competitive exclusion of pathogens, enhancement of intestinal barrier integrity, immune modulation and regulation of microbial metabolites such as short-chain fatty acids. Their mitigating effects against heat stress, suboptimal rearing environments, mycotoxin contamination, heavy metal exposure and immune stress are analyzed. We further evaluate the capacity of single and compound probiotics to control major poultry diseases. Early-life intervention strategies and innovative preparations (multistrain probiotics, synbiotics, postbiotics) are systematically summarized. Critical bottlenecks restricting industrial translation are highlighted, including empirical strain combination, non-standardized administration protocols, divergent evaluation indicators and single-factor laboratory challenge models inconsistent with actual farm conditions. Finally, we propose future research directions covering multi-omics-assisted strain screening, optimized delivery technology, unified industrial quality control standards and field verification under compound stress. This review offers integrated references for mechanistic research, strain development and precise industrial application of probiotics in sustainable antibiotic-free poultry breeding.

Indexed as

antibiotic alternativesgut microbiotaintestinal healthpoultryprobiotics

Identifiers

PMID42655851
PMCPMC13517542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.