Evidence map›Paper›PMID 42655720›Full record

ArticleViruses2026

Seroepidemiology of Enterovirus D68 in Xiamen Children: A Cross-Sectional Study in 2022.

Liting Wang, Qiguo Zhu, Yi Lu, Yuanyuan Wu, Zhifeng Ke, Qingbing Zheng, Longfa Xu, Tong Cheng, Rui Zhu, Jun Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liting WangInfectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.ORCID 0000-0001-7168-1585
Qiguo ZhuXiamen Children's Hospital, Xiamen Branch of Children's Hospital of Fudan University, Xiamen 361006, China.
Yi LuXiamen Children's Hospital, Xiamen Branch of Children's Hospital of Fudan University, Xiamen 361006, China.
Yuanyuan WuState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361005, China.
Zhifeng KeState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361005, China.
Qingbing ZhengState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361005, China.ORCID 0000-0002-7516-9965
Longfa XuState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361005, China.
Tong ChengState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361005, China.ORCID 0000-0002-1638-6214
Rui ZhuState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361005, China.
Jun ShenInfectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.ORCID 0000-0002-8759-6921

Funding

Nantong Municipal Key Medical Discipline NoneNational Natural Science Foundation of China 32170942National Natural Science Foundation of China 32470996
6 · The paper itself

Abstract

Enterovirus D68 (EV-D68) is a re-emerging pathogen associated with severe acute flaccid myelitis (AFM) and pneumonia, predominantly in children but also capable of causing severe disease in immunocompromised adults. Seroprevalence data are essential for understanding population immunity, age-specific susceptibility, and viral transmission dynamics; yet, such data for the period after the COVID-19 pandemic are scarce. We conducted a cross-sectional serological survey to characterize the neutralizing antibody profile of EV-D68 among children in Xiamen, China, in 2022. A total of 453 children aged 0-16 years (217 with acute respiratory tract infection [ARTI] and 236 without) were enrolled. Neutralizing antibody (NtAb) titers against the EV-D68 STL strain were measured using a microneutralization assay, seropositivity was defined as a titer ≥1:16. Multivariable regression and analysis of covariance were used to adjust for age and sex. Overall seroprevalence was 96.0% (435/453), exceeding 90.0% in every age subgroup (0-1 y: 100%; 1-3 y: 97.6%; 3-5 y: 92.6%; ≥5 y: 96.2%). The geometric mean titer (GMT) was 76.78 (95% CI: 68.32-85.24). After adjustment, ARTI status was not significantly associated with seropositivity (adjusted OR = 1.42, 95% CI: 0.46-4.41,

Indexed as

Antibodies, ViralEnterovirus D, HumanEnterovirus InfectionsAdolescentAntibodies, NeutralizingChildChild, PreschoolChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleRespiratory Tract InfectionsSeroepidemiologic StudiesAntibodies, NeutralizingAntibodies, Viralchildrenenterovirus D68neutralizing antibodiesseroepidemiologyseroprevalence

Identifiers

PMID42655720
PMCPMC13517125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.