Weight Gain Is Associated with Short-Term FIB-4 Increase and Concurrent Metabolic Change in People with HIV and Metabolic Dysfunction-Associated Steatotic Liver Disease.

Wei Xu, Li Liu, Meiyan Sun, Renfang Zhang, Jun Chen, Yinzhong Shen

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Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Wei XuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Li LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Meiyan SunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Renfang ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Jun ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Yinzhong ShenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.ORCID 0000-0002-7604-5139

Funding

Shanghai Hospital Development Center SHDC2025CCS030Shanghai Hospital Development Center SHDC22024317

6 · The paper itself

Abstract

backgroundShort-term variation in the Fibrosis-4 index (FIB-4) may identify people who warrant further liver assessment. We evaluated longitudinal FIB-4 changes and associated metabolic factors in people with HIV (PWH) and metabolic dysfunction-associated steatotic liver disease (MASLD).

methodsThis retrospective cohort included 683 PWH with ultrasound-defined MASLD who underwent routine clinical and laboratory assessments approximately every three months. A prespecified FIB-4 increase required both a ≥20% rise and crossing to ≥1.3 among participants with baseline FIB-4 < 1.3, or a ≥20% rise among those with baseline FIB-4 ≥ 1.3.

resultsOf 683 enrolled participants, 655 were analyzed longitudinally. Over a median follow-up of 12.0 months, 59 (9.0%) met the FIB-4 increase definition, corresponding to 8.8 events per 100 person-years. Weight gain was associated with this outcome (adjusted hazard ratio 1.19 per 1% increase, 95% CI 1.14-1.24), whereas HIV- and antiretroviral therapy-related variables were not. Transition from non-obesity to obesity was associated with the outcome (odds ratio 8.45, 95% CI 3.57-20.02). Weight change also correlated with concurrent changes in total cholesterol, triglycerides, fasting glucose, and liver enzymes (all

conclusionsWeight gain was associated with short-term FIB-4 increase and with concurrent metabolic change in PWH with MASLD.

Indexed as

Fatty LiverHIV InfectionsMetabolic DiseasesWeight GainAdultFemaleHumansLiverLongitudinal StudiesMaleMiddle AgedRetrospective StudiesFIB-4HIVlongitudinal changemetabolic dysfunction-associated steatotic liver diseaseobesityweight gain

Identifiers

PMID42655713

DOI10.3390/v18080896

PMCPMC13517362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.