Evidence map›Paper›PMID 42655689›Full record

ReviewViruses2026

Putting Evolution to Work: Host Range Alteration for Phage Therapy.

Rachel Stanchek, Paul Hyman

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rachel StanchekDepartment of Biology & Toxicology, Ashland University, Ashland, OH 44805, USA.
Paul HymanDepartment of Biology & Toxicology, Ashland University, Ashland, OH 44805, USA.ORCID 0000-0002-0108-4993

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Host range describes the hosts that a bacteriophage can and cannot infect. Throughout the history of phage use in various applications, phages with varying host ranges have been needed and techniques to alter a phage's host range have been developed. These include techniques that rely on spontaneous mutations and others that use genetic engineering to make designed changes. Phages with altered host ranges have been used in personalized phage therapy cases and in cocktails in clinical trials. In this review, we provide descriptions of methods for altering a phage's host range with a focus on applications to phage therapy.

Indexed as

BacteriophagesHost SpecificityPhage TherapyAnimalsBacteriaEvolution, MolecularGenetic EngineeringHumansMutationantibiotic-resistant bacteriabacteriophageevolutiongenetic engineeringhost rangemutationphage therapyreceptor binding protein

Identifiers

PMID42655689
PMCPMC13517834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.