Evidence map›Paper›PMID 42655681›Full record

ReviewViruses2026

Current Strategies for Selecting Recombinant Orthopoxvirus Proteins for Immunobiological and Diagnostic Applications.

Aigerim Zhakypbek, Lespek Kutumbetov, Gulnur Kuzembekova, Kamshat Shorayeva, Nurlan Kozhabergenov, Bekbolat Usserbayev, Gulnur Nakhanova, Kuanysh Jekebekov, Gaukhar Shynybekova, Akbope Abdykalyk and 5 more

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aigerim ZhakypbekResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Lespek KutumbetovResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Gulnur KuzembekovaDepartment of Microbiology, Virology and Immunology, Faculty of Veterinary Science and Zooengineering, Kazakh National Agrarian Research University, Almaty 050010, Kazakhstan.
Kamshat ShorayevaResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Nurlan KozhabergenovResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.ORCID 0000-0001-6299-9399
Bekbolat UsserbayevResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.ORCID 0000-0002-4615-1328
Gulnur NakhanovaResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Kuanysh JekebekovResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Gaukhar ShynybekovaResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.ORCID 0000-0002-6976-1540
Akbope AbdykalykResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.ORCID 0000-0002-1998-8798
Aknur UlankyzyResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Temirlan BaiseitResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Balzhan MyrzakhmetovaResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.
Olga ChervyakovaResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.ORCID 0000-0002-7954-6246
Kuandyk ZhugunissovResearch Institute for Biological Safety Problems, National Holding QazBioPharm, Gvardeiskiy 080409, Kazakhstan.ORCID 0000-0003-4238-5116

Funding

Ministry of Healthcare of the Republic of Kazakhstan BR28712529
6 · The paper itself

Abstract

Orthopoxviruses are zoonotic DNA viruses of continuing public health importance, as highlighted by recent global mpox outbreaks. The high antigenic similarity among orthopoxviruses enables cross-reactive immune responses but complicates the development of serological diagnostic systems for serosurveillance, assessment of previous exposure, evaluation of vaccine-induced immunity, and species differentiation. This review summarizes current knowledge regarding the structure, biological functions, and diagnostic and vaccine potential of major orthopoxvirus recombinant antigens. Particular attention is given to the genomic organization of

Indexed as

Antigens, ViralOrthopoxvirusPoxviridae InfectionsRecombinant ProteinsViral ProteinsAnimalsAntibodies, ViralHumansPhylogenyProtein Subunit VaccinesViral VaccinesAntibodies, ViralAntigens, ViralProtein Subunit VaccinesRecombinant ProteinsViral ProteinsViral VaccinesimmunogenicityIMV and EEV antigensmonkeypox virusorthopoxvirusphylogenetic analysisrecombinant antigensserological diagnosticssubunit vaccines

Identifiers

PMID42655681
PMCPMC13517126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.