Evidence map›Paper›PMID 42655680›Full record

ArticleViruses2026

Pan-Viral Sequencing Surveillance Identifies Mammalian Orthoreovirus 2 in United States Wastewater.

John P Collins, Michael A Mechikoff, Thomas A Pressley, Catherine R Jarriel, Riley E M Russell, Cullen Ingersoll, Xiang-Jun Lu, Thomas Briese, Armand L Balboni, J Kenneth Wickiser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

John P CollinsGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY 10032, USA.ORCID 0009-0002-6691-6583
Michael A MechikoffDepartment of Biology, US Air Force Academy, Colorado Springs, CO 80840, USA.
Thomas A PressleyLife Sciences Research Center, US Air Force Academy, Colorado Springs, CO 80840, USA.
Catherine R JarrielLife Sciences Research Center, US Air Force Academy, Colorado Springs, CO 80840, USA.
Riley E M RussellDepartment of Biology, US Air Force Academy, Colorado Springs, CO 80840, USA.
Cullen IngersollDepartment of Biology, US Air Force Academy, Colorado Springs, CO 80840, USA.
Xiang-Jun LuGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Thomas BrieseGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Armand L BalboniLife Sciences Research Center, US Air Force Academy, Colorado Springs, CO 80840, USA.
J Kenneth WickiserGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY 10032, USA.ORCID 0000-0002-5034-2100

Funding

Defense Health AgencySkoll FoundationUnited States Air Force Office of Scientific Research
6 · The paper itself

Abstract

Mammalian orthoreoviruses (MRVs) are segmented, double-stranded RNA viruses that infect a broad range of mammalian hosts, including humans. Although MRVs have been detected in wastewater in parts of Southeast Asia, they have not previously been reported in U.S. wastewater. Using the VirCapSeq-VERT pan-viral sequencing assay, we identified MRV type 2 (MRV-2) in a wastewater sample collected in March 2024 from the United States Air Force Academy. Complete genome sequences were recovered for all 10 segments. Phylogenetic analyses showed that the virus clustered most closely with an MRV isolate recovered from a big brown bat (

Indexed as

Orthoreovirus, MammalianWastewaterAnimalsChiropteraGenome, ViralPhylogenyRNA, ViralUnited StatesRNA, ViralWastewaterreovirusviral genomicsVirCapSeq-VERTwastewater-based epidemiologywastewater surveillance

Identifiers

PMID42655680
PMCPMC13517694

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.