ArticleViruses2026
Dual Antiviral Functions of Antibodies Targeting African Swine Fever Virus p17 Protein: Viral Inhibition and ADCC Induction.
Shengmei Chen, Chunhao Jiang, Zhanhao Lu, Jing Lan, Qiang Fu, Yuan Sun, Tao Wang, Hua-Ji Qiu
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In one paragraphArticle in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Shengmei ChenState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.ORCID 0009-0004-4297-2470 Chunhao JiangState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Zhanhao LuState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Jing LanState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Yuan SunState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Tao WangState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.ORCID 0000-0002-0834-4372 Hua-Ji QiuState Key Laboratory of Animal Disease Control and Prevention, Professional Laboratory for African Swine Fever (Harbin), National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.ORCID 0000-0003-4880-5687 Funding
Central Publicinterest Scientific Institution Basal Research 1610302025009National Natural Science Foundation of China 32202774National Natural Science Foundation of China 32430102National Natural Science Foundation of China 32573396
6 · The paper itselfAbstract
African swine fever virus (ASFV) causes African swine fever (ASF), a highly lethal disease in pigs. Vietnam has approved two ASF live-attenuated vaccines (LAVs), but their efficacy and safety remain controversial, and no reliable, highly effective commercial ASF vaccine is available yet. Humoral immunity plays an important role in protection against ASFV infection. However, there is still controversy regarding whether ASFV infection can induce antibodies with neutralizing activity. Antibody-dependent cellular cytotoxicity (ADCC), as an antibody-mediated protective mechanism, offers a novel perspective for screening protective ASFV antigens. This study evaluated five structural proteins (pCP312R, pA104R, pA151R, p17, and pF317L) as subunit vaccine candidates based on their ability to induce antibodies that inhibit viral replication and mediate ADCC. The recombinant proteins were expressed in
Indexed as
African Swine FeverAfrican Swine Fever VirusAntibodies, ViralAntibody-Dependent Cell CytotoxicityViral Structural ProteinsAnimalsAntibodies, NeutralizingHEK293 CellsHumansLeukocytes, MononuclearMacrophages, AlveolarProtein Subunit VaccinesSwineViral VaccinesVirus ReplicationAntibodies, NeutralizingAntibodies, ViralProtein Subunit VaccinesViral Structural ProteinsViral VaccinesAfrican swine feverAfrican swine fever virusantibody-dependent cellular cytotoxicityp17
Identifiers
PMID42655659
PMCPMC13517651
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