ArticleViruses2026
The FIB-4 Is a Marker of Monocyte/Macrophage Activation Independently from Severe Hepatic Disease in People Living with HIV on Stable and Successful Treatment.
Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
objectivesDespite successful antiretroviral treatment (ART), people living with HIV (PWH) continue experiencing chronic immune activation and comorbidities. We analysed whether the Fibrosis 4 index (FIB-4) is associated with monocyte-macrophage activation in PWH with non-severe hepatic disease. MATERIALS AND
methodsWe performed a cross-sectional analysis about factors associated with monocyte-macrophage activation among PWH either on triple or dual ART. Background measurements, comorbid conditions and FIB-4 values were correlated with plasmatic markers of monocyte-macrophage activation (sCD163 and sCD14) using univariate and linear regression analysis.
resultsWe included 366 subjects (age 60.5, 75% male, years of HIV infection 24.5, mean FIB-4 1.52, 8% with FIB-4 > 2.67, Body Mass Index 24.5). In univariate analysis, FIB-4 was associated with older age, years of HIV infection, ART duration, lower CD4/CD8 ratio at inclusion, lower nadir CD4, higher sCD14 and sCD163 values, living alone, dyslipidaemia, high blood pressure and diabetes (
conclusionsThe FIB-4 is a simple tool reliable for monocyte-macrophage activation in PWH, able to define subjects with higher risks of complications.
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