Evidence map›Paper›PMID 42655196›Full record

ArticleMicroorganisms2026

Itaconic Acid Directly Binds to the Cysteine Residue of PurF: A Novel Mechanism for Inhibiting Purine Metabolism in Porcine Pathogenic

Haozhen Liu, Xin Li, Xinyu Zhang, Yao Ge, Yinfeng Chen, Xinjian Li, Zhenlong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haozhen LiuState Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China.
Xin LiState Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China.
Xinyu ZhangState Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China.
Yao GeState Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China.
Yinfeng ChenState Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China.
Xinjian LiState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zhenlong WuState Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China.

Funding

National Natural Science Foundation of China 32172749
6 · The paper itself

Abstract

Itaconic acid has been reported to possess anti-inflammatory and antibacterial properties. However, its specific mechanisms of action against pathogenic bacteria, especially in the context of purine metabolism, remain poorly understood. Here, we investigate the impact of itaconic acid on the purine metabolism of PCN033, a highly pathogenic porcine extraintestinal pathogenic

Indexed as

itaconic acidporcine extraintestinal pathogenic Escherichia coli (PCN033)PRPP amidotransferase (PurF)purine metabolism

Identifiers

PMID42655196
PMCPMC13515712

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.