ESM2-Guided Context-Aware Annotation Completion Supplements Carbohydrate Metabolism Coverage in Silage Microbial Metagenomes.

Jiewei Zhang, Xinyu Du, Jinbiao Tang, Xiaoning Dong, Xusheng Guo, Mingxue Li, Dongmei Xu

Abstract read

In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiewei ZhangSchool of Electrical Engineering, Northwest Minzu University, Lanzhou 730030, China.ORCID 0009-0004-6624-9260

Xinyu DuSchool of Electrical Engineering, Northwest Minzu University, Lanzhou 730030, China.ORCID 0009-0009-0586-8187

Jinbiao TangSchool of Electrical Engineering, Northwest Minzu University, Lanzhou 730030, China.ORCID 0009-0000-5231-2629

Xiaoning DongSchool of Electrical Engineering, Northwest Minzu University, Lanzhou 730030, China.ORCID 0009-0001-9888-614X

Xusheng GuoSchool of Life Sciences, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0002-5587-3920

Mingxue LiSchool of Electrical Engineering, Northwest Minzu University, Lanzhou 730030, China.ORCID 0000-0001-7666-1954

Dongmei XuSchool of Life Sciences, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0003-3359-9702

Funding

Gansu Education Department 2024B-034Northwest Minzu University 00400-Z2200603Northwest Minzu University 31920240123Northwest Minzu University 31920260001‑091

6 · The paper itself

Abstract

Functional annotation gaps limit the interpretation of carbohydrate metabolism in silage microbiomes. We developed Context-Aware Annotation Completion (CAAC), a framework integrating ESM2 embeddings, genomic-neighborhood features, three-class classification, confidence-tiered neighbor voting, and Enzyme Commission (EC)-to-KEGG Orthology (KO) mapping. CAAC was applied to 21 metagenomes from uninoculated and

Indexed as

carbohydrate-active enzymesfunctional annotationgenomic contextmetagenomicsprotein language modelsilage microbiome

Identifiers

PMID42655191

DOI10.3390/microorganisms14081848

PMCPMC13515629

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.