Temporal Trends in Pathogens and Clinical Outcomes of Adult Deep Neck Infections: An 18-Year Multicenter Cohort Study of 12,063 Cases.

Fang-Ching Liu, Ang Lu, Pei-Rung Yang, Yao-Te Tsai, Yao-Hsu Yang, Chia-Yen Liu, Geng-He Chang

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Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Fang-Ching LiuDepartment of Pediatrics, Jen-Ai Hospital, Taichung 412, Taiwan.

Ang LuDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, No.8, W. Sec., Jiapu Rd., Chiayi 613, Taiwan.ORCID 0009-0003-0361-0090

Pei-Rung YangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.ORCID 0000-0003-0808-1119

Yao-Te TsaiDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, No.8, W. Sec., Jiapu Rd., Chiayi 613, Taiwan.

Yao-Hsu YangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.ORCID 0000-0002-8080-0504

Chia-Yen LiuHealth Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi 613, Taiwan.

Geng-He ChangDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, No.8, W. Sec., Jiapu Rd., Chiayi 613, Taiwan.ORCID 0000-0001-5939-9747

Funding

Jen-Ai Hospital JMRPGJN0091

6 · The paper itself

Abstract

Adult deep neck infection (DNI) is a potentially life-threatening condition associated with significant morbidity and mortality. Contemporary large-scale data characterizing long-term microbial evolution and clinical outcome trends in adult DNI remain limited. This study aimed to investigate temporal changes in bacterial pathogens, treatment strategies, and clinical outcomes of adult DNI across an 18-year period. This is a retrospective multicenter cohort study using the Chang Gung Research Database (CGRD) and a de-identified nationwide database from Taiwan's largest medical system. Hospitalized adult patients (aged ≥18 years) with DNI from 2006 to 2023 were identified and stratified into two consecutive 9-year epochs (Epoch 1: 2006-2014,

Indexed as

adult deep neck infectionbacterial etiologyempiric antibiotic therapymethicillin-resistant Staphylococcus aureusStreptococcus anginosus grouptemporal trends

Identifiers

PMID42655170

DOI10.3390/microorganisms14081826

PMCPMC13515096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.