Evidence map›Paper›PMID 42655030›Full record

ArticleMicroorganisms2026

Synthesis and Biological Evaluation of Novel C-28 Chloroacetamide-Modified Ursolic Acid Derivatives as Antibacterial Agents.

Nan Cai, Tian Luan, Junchao Zhang, Ning Li, Xiu Zhang, Peng Gao, Jiaxuan Li, Hongyu Zhan, Fanhao Meng, Dajun Zhang

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nan CaiShenyang Key Laboratory for Phenomics, Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shenyang 110034, China.ORCID 0000-0002-6696-0966
Tian LuanShenyang Key Laboratory for Phenomics, Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shenyang 110034, China.ORCID 0000-0003-4284-7990
Junchao ZhangSchool of Pharmacy, China Medical University, Shenyang 110122, China.
Ning LiShenyang Key Laboratory for Phenomics, Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shenyang 110034, China.
Xiu ZhangShenyang Key Laboratory for Phenomics, Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shenyang 110034, China.
Peng GaoFaculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-6877-6388
Jiaxuan LiFaculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.
Hongyu ZhanFaculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.
Fanhao MengSchool of Pharmacy, China Medical University, Shenyang 110122, China.ORCID 0000-0002-1331-2164
Dajun ZhangShenyang Key Laboratory for Phenomics, Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shenyang 110034, China.

Funding

Department of Science and Technology of Liaoning Province 2025-BS-0858Department of Science and Technology of Liaoning Province 2025-MS-293Department of Science and Technology of Liaoning Province 2026JH2/102100008
6 · The paper itself

Abstract

The escalating crisis of bacterial antimicrobial resistance necessitates the discovery of novel antibacterial agents with distinct mechanisms of action. Ursolic acid (UA), a naturally abundant pentacyclic triterpenoid, serves as a promising scaffold for structural modification. In this study, a series of 26 novel UA derivatives (

Indexed as

antibacterial activitybiofilm inhibitionSarAstructure modificationursolic acid

Identifiers

PMID42655030
PMCPMC13515426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.