ArticlePathogens (Basel, Switzerland)2026
In Vitro and In Silico Evaluation of the Anti-Infective Potential of EF24-Analogous Curcuminoids: Antiprotozoal Activity and HIV-1 Ribonuclease H Inhibition.
Tariq A Khan, Ibrahim S Al Nasr, Waleed S Koko, Kamal A Qureshi, Nhat Quang Tu, Clémence Richetta, Federica Putzu, Laura Dettori, Olivier Delelis, Rainer Schobert and 2 more
Abstract read
In one paragraphArticle in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Tariq A KhanDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0001-6184-5929 Ibrahim S Al NasrDepartment of Biology, College of Science, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0003-4690-1050 Waleed S KokoDepartment of Biology, College of Science, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0002-7773-995X Kamal A QureshiDepartment of Pharmaceutics, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.ORCID 0000-0002-3498-797X Nhat Quang TuLaboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS-Paris-Saclay, Centre National de la Recherche Scientifique (CNRS) UMR 8113, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.ORCID 0000-0001-7451-9671 Clémence RichettaLaboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS-Paris-Saclay, Centre National de la Recherche Scientifique (CNRS) UMR 8113, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.ORCID 0000-0003-4685-5859 Federica PutzuLaboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari Biomedical Section, E Block, First Floor, Cittadella Universitaria di Monserrato SS554, 09042 Monserrato, CA, Italy.ORCID 0009-0000-6433-8615 Laura DettoriLaboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari Biomedical Section, E Block, First Floor, Cittadella Universitaria di Monserrato SS554, 09042 Monserrato, CA, Italy.ORCID 0009-0005-5101-4992 Olivier DelelisLaboratoire de Biologie et Pharmacologie Appliquée (LBPA), ENS-Paris-Saclay, Centre National de la Recherche Scientifique (CNRS) UMR 8113, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
Rainer SchobertOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95447 Bayreuth, Germany.ORCID 0000-0002-8413-4342 Angela CoronaLaboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari Biomedical Section, E Block, First Floor, Cittadella Universitaria di Monserrato SS554, 09042 Monserrato, CA, Italy.ORCID 0000-0002-6630-8636 Bernhard BiersackOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95447 Bayreuth, Germany.ORCID 0000-0001-7305-346X Funding
EU MUR PNRR PE00000007
6 · The paper itselfAbstract
Curcumin derivatives (curcuminoids) exhibit considerable antiparasitic and antiviral activities. In this study, EF24-like bis-2-fluorobenzylidene piperidone derivatives were synthesized and evaluated for antiprotozoal activity and inhibition of the human immunodeficiency virus (HIV)-1 reverse transcriptase (RT)-associated RNase H (HIV-1 RNase H). A series of bis-arylidene piperidones and tetrahydro(thio)pyranones bearing halogen or nitro substituents were tested against
Indexed as
Antiprotozoal AgentsCurcuminHIV-1Ribonuclease HRibonuclease H, Human Immunodeficiency VirusAnimalsEnzyme InhibitorsHumansInhibitory Concentration 50LeishmaniaToxoplasmaAntiprotozoal AgentsCurcuminEnzyme InhibitorsRibonuclease HRibonuclease H, Human Immunodeficiency Virusantiparasitic agentscurcuminoidsEF24 analogshalogenHIVleishmaniasismolecular dockingRNase H inhibitortoxoplasmosis
Identifiers
PMID42654813
PMCPMC13516635
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