ArticlePathogens (Basel, Switzerland)2026
Implementation of a Composite Reference Standard Methodology in the Greek National Malaria Reference Center, Insights from a Seven-Year Experience.
Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMalaria is currently ranked as an important public health issue in Greece despite its initial eradication back in 1974. Given that the clinical picture is often nonspecific, the need for the implementation of targeted laboratory methodologies is imperative to ensure prompt
methodsA total of 780 clinical samples from 763 suspected malaria cases from the National Malaria Reference Center were analyzed within a seven-year period (2017-2023). A composite laboratory reference standard methodology, including rapid diagnostic testing, microscopy, and polymerase chain reactions, was implemented for the purposes set by the current study in a group of 532 samples. A multivariable statistical analysis was implemented for the interpretation of the extracted data.
resultsMicroscopy and PCR successfully identified
conclusionsThe current study highlighted the importance of microscopic examination in malaria diagnostic procedures for
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