Evidence map›Paper›PMID 42654172›Full record

ArticleNutrients2026

Dietary Patterns and Cognitive Decline in Older Adults: Findings from the Western Australia Memory Study.

Carolina Blagojevic Castro, Samantha L Gardener, Farzana Jahan, Juliana Chen, Belinda M Brown, Ruey L Loo, Kevin Taddei, Stephanie R Rainey-Smith, Michael Weinborn, Ana Caroline R Dos Reis and 3 more

Abstract read
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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carolina Blagojevic CastroCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-7176-4823
Samantha L GardenerAlzheimer's Research Australia, Nedlands, WA 6009, Australia.ORCID 0000-0002-1933-5260
Farzana JahanCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0002-0300-6315
Juliana ChenFaculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0003-2844-6947
Belinda M BrownCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.
Ruey L LooAustralian National Phenome Centre and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia.ORCID 0000-0001-5307-5709
Kevin TaddeiAlzheimer's Research Australia, Nedlands, WA 6009, Australia.
Stephanie R Rainey-SmithCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.
Michael WeinbornSchool of Psychological Science, The University of Western Australia, Crawley, WA 6009, Australia.
Ana Caroline R Dos ReisDepartment of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.
Manohar L GargMacquarie Medical School, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0003-0514-0865
Ralph N MartinsAlzheimer's Research Australia, Nedlands, WA 6009, Australia.ORCID 0000-0002-4828-9363
Hamid R SohrabiCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0001-8017-8682

Funding

Department of Jobs, Tourism, Science and Innovation #324100
6 · The paper itself

Abstract

backgroundPreventive strategies, including adherence to specific dietary patterns, have received increasing attention as approaches to reduce cognitive decline and dementia risk. However, findings remain inconsistent, partly due to differences in dietary assessment methods, cognitive outcomes, and THE consideration of genetic susceptibility factors such as apolipoprotein E (

methodsThis study examined associations between dietary patterns and longitudinal cognitive change in 185 older adults without dementia from the Western Australia Memory Study. Participants completed a food frequency questionnaire at baseline and underwent comprehensive neuropsychological assessments at baseline and up to five follow-up visits at 18-month intervals. Composite scores were generated for six cognitive domains and the Preclinical Alzheimer's Cognitive Composite (PACC).

resultsWestern and Prudent dietary pattern scores were analysed using linear mixed-effects models stratified by

conclusionThese findings suggest that adherence to a Western dietary pattern may accelerate cognitive decline in individuals genetically at risk for Alzheimer's disease, highlighting the importance of considering gene-diet interactions when developing dietary strategies for dementia prevention.

Indexed as

CognitionCognitive DysfunctionDietDiet, WesternFeeding BehaviorAgedAged, 80 and overAlzheimer DiseaseApolipoprotein E4FemaleGenetic Predisposition to DiseaseGenotypeHumansLongitudinal StudiesMaleMemoryApolipoprotein E4Alzheimer’s diseaseAPOE ε4 genotypeattentioncognitioncognitive declinedietary patterns

Identifiers

PMID42654172
PMCPMC13516335

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.