Trial reportNutrients2026
Football-Specific Performance and Cognitive Fatigue Resistance Following Supplementation with Two Phosphatidylserine Doses Combined with Taurine and Caffeine in Professional Male Football Players: A Randomized, Triple-Masked, Placebo-Controlled Trial.
Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesCognitive fatigue and impaired psychomotor function may contribute to reductions in football-specific performance during prolonged match-like activity. This study evaluated cognitive, psychomotor, sprint, and football-specific locomotor responses to multi-ingredient protocols containing taurine, caffeine, and either 300 or 600 mg·day
methodsIn this randomized, triple-masked, placebo-controlled, parallel-group trial, 97 professional male football players were allocated to placebo (PLA,
resultsThe baseline-adjusted ANCOVA demonstrated a significant treatment-group effect on post-intervention 30 m sprint time. After Holm-Bonferroni correction, significant treatment-related effects remained for Stroop reaction time, visual reaction time, and perceived mental fatigue. No statistically significant treatment-related effect was observed for auditory reaction time (unadjusted
conclusionsUnder the present 14-day experimental conditions, the multi-ingredient protocols containing taurine, caffeine, and phosphatidylserine were associated with more favorable selected cognitive and psychomotor outcomes, 30 m sprint performance, and baseline-adjusted GPS-derived locomotor outcomes than placebo. The groups also differed in post-intervention first-to-second-half performance loss during the standardized football-specific protocol. Because corresponding decline indices were not assessed at baseline, these findings do not demonstrate an intervention-related improvement in fatigue resistance. Numerically more favorable values were observed for several outcomes in TCP-600; however, differences between TCP-300 and TCP-600 were modest and not consistently statistically significant, and the study was not specifically powered to establish a dose-response relationship. Because phosphatidylserine was not tested independently, these findings should be interpreted as responses to the combined multi-ingredient supplementation protocols rather than as effects of phosphatidylserine alone.
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