Evidence map›Paper›PMID 42654149›Full record

ArticlePharmaceutics2026

Engineering Allogeneic FE002-Cart Chondroprogenitor Spheroids for Large Knee Chondral Defects: Investigating Microenvironmental Cues for Functional Control, GMP Formulation, and Logistical Viability.

Lee Ann Applegate, Farid Hadjab, Sandra Jaccoud, Alexandre Porcello, Virginie Philippe, Nathalie Hirt-Burri, Corinne Scaletta, Brigitte M Jolles, Dominique P Pioletti, Robin Martin and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lee Ann ApplegateRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.ORCID 0000-0002-7346-9921
Farid HadjabDevelopment Department, Albomed GmbH, D-90592 Schwarzenbruck, Germany.
Sandra JaccoudRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.
Alexandre PorcelloDevelopment Department, LOUNA REGENERATIVE SA, CH-1228 Plan-les-Ouates, Switzerland.ORCID 0000-0003-1603-2704
Virginie PhilippeRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.ORCID 0000-0003-3544-0383
Nathalie Hirt-BurriRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.ORCID 0000-0003-1220-0213
Corinne ScalettaRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.ORCID 0000-0002-7682-9160
Brigitte M JollesDepartment of Musculoskeletal Medicine, Swiss BioMotion Lab, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), CH-1011 Lausanne, Switzerland.
Dominique P PiolettiLaboratory of Biomechanical Orthopedics, Federal Polytechnic School of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0001-5535-5296
Robin MartinOrthopedic Surgery Service, Fribourg Hospital, CH-1752 Villars-sur-Glâne, Switzerland.
Alexis E LaurentManufacturing Department, LAM Biotechnologies SA, CH-1066 Epalinges, Switzerland.ORCID 0000-0001-5738-8702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

advanced therapy medicinal products (ATMP)allogeneic cytotherapiescartilage tissue engineeringcell formulationchondrogenesisgood manufacturing practice (GMP)hypoxiamanufacturing processoff-the-shelf implantsthree-dimensional spheroids

Identifiers

PMID42654149
PMCPMC13516314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.