Evidence map›Paper›PMID 42654147›Full record

ArticlePharmaceutics2026

Physiologically Based Pharmacokinetic (PBPK) Modeling of FIX in Pediatric Hemophilia B: Extravascular Distribution and Dosing Optimization.

Mengmeng Liu, Guoqing Liu, Qixian Ling, Yongbo Chen, Haojie Xu, Runhui Wu, Zhenping Chen, Libo Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengmeng LiuDepartment of Pharmacy, Peking University Third Hospital, Beijing 100191, China.ORCID 0000-0002-9872-4212
Guoqing LiuHemophilia Comprehensive Care Center, Hematology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Qixian LingDepartment of Pharmacy, Peking University Third Hospital, Beijing 100191, China.
Yongbo ChenDepartment of Pharmacy, Peking University Third Hospital, Beijing 100191, China.
Haojie XuDepartment of Pharmacy, Peking University Third Hospital, Beijing 100191, China.ORCID 0009-0007-3275-261X
Runhui WuHemophilia Comprehensive Care Center, Hematology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Zhenping ChenHemophilia Comprehensive Care Center, Hematology Department, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Libo ZhaoDepartment of Pharmacy, Peking University Third Hospital, Beijing 100191, China.

Funding

Beijing Municipal Administration of Hospitals PX2024043Peking University Third Hospital BYSYZD2021002
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

dose optimizationextravascular distributionfactor IXhemophilia BPBPK modelingpediatric population

Identifiers

PMID42654147
PMCPMC13516121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.