Evidence map›Paper›PMID 42654097›Full record

ArticlePharmaceutics2026

Clazosentan Attenuates Endothelin-1-Induced ETA Protein Upregulation and Contractile Sensitization in Brain Pericytes.

Genki Chikamatsu, Shinsuke Nakagawa, Yoichi Morofuji, Eri Shiozaki, Yuka Ogawa, Kazuaki Okamura, Yuki Matsunaga, Daisuke Watanabe, Fruzsina R Walter, Tsuyoshi Izumo and 3 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Genki ChikamatsuDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.ORCID 0009-0002-7376-1305
Shinsuke NakagawaDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.ORCID 0000-0001-7945-9719
Yoichi MorofujiDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.ORCID 0000-0001-7135-2220
Eri ShiozakiDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.ORCID 0000-0003-1358-7472
Yuka OgawaDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.
Kazuaki OkamuraDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.
Yuki MatsunagaDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.ORCID 0000-0001-5562-9883
Daisuke WatanabeBBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki 852-8135, Japan.ORCID 0000-0001-6916-4060
Fruzsina R WalterBiological Barriers Research Group, Institute of Biophysics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.ORCID 0000-0001-8145-2823
Tsuyoshi IzumoDepartment of Neurosurgery, Gifu University Hospital, Gifu City 501-1194, Japan.
Masami NiwaBBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki 852-8135, Japan.ORCID 0000-0001-5138-5180
Maria A DeliBiological Barriers Research Group, Institute of Biophysics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.ORCID 0000-0001-6084-6524
Takayuki MatsuoDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.

Funding

Hungarian Academy of Sciences NKM2022-9/2023Hungarian Academy of Sciences NKM2025-7/2025Japan Society for the Promotion of Science 20K09351Japan Society for the Promotion of Science 20KK0254Japan Society for the Promotion of Science JPJSBP120203804
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

brain pericyteclazosentancontractile sensitizationdrug–receptor interactionendothelin-1endothelin type A receptorETA receptor antagonistneurovascular unitpharmacodynamics

Identifiers

PMID42654097
PMCPMC13516358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.