ArticleMolecules (Basel, Switzerland)2026
An Integrated Two-Stage Strategy for Efficient Lactic Acid Production via Ionic Liquid-Assisted Mechanochemical Pretreatment and Catalytic Conversion.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Efficient conversion of cellulose to value-added lactic acid remains challenging because the rigid crystalline structure of cellulose limits its accessibility and subsequent conversion. This study developed an integrated strategy combining ionic liquid-assisted ball milling with catalytic lactic acid production. Ionic liquid type, ball-milling time, ionic liquid concentration, and glucose addition were examined during cellulose pretreatment. Among the ionic liquids tested, 1-butyl-3-methylimidazolium acetate ([Bmim][OAc]) provided the highest apparent water-soluble fraction. After 60 min of ball milling with 0.17 M [Bmim][OAc], the apparent water-soluble fraction increased from 5.1% for untreated cellulose to 63.7%, while the crystallinity index decreased from 78.1% to 44.0%. The catalytic stage was then evaluated using D-glucose as a model substrate with rehydrated hydrotalcite (r-HT) in a Ba(OH)
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