Evidence map›Paper›PMID 42653996›Full record

ArticleMolecules (Basel, Switzerland)2026

Design, Synthesis, and Structure-Activity Relationships of Novel Piperidine-Fused Imidazolone ClpP Activators as Potential Anti-Cancer Agents.

Shanshan Chen, Xinyi Lin, Min Guo, Ruqi Lei, Beijing Chen, Yubo Zhou, Aijun Qiao, Qi Huang, Mingliang Wang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shanshan ChenSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Xinyi LinSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Min GuoSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ruqi LeiGuangzhou University of Chinese Medicine, Guangzhou 510006, China.
Beijing ChenZhongshan Institute for Drug Discovery, Zhongshan 528400, China.
Yubo ZhouSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Aijun QiaoSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Qi HuangZhongshan Institute for Drug Discovery, Zhongshan 528400, China.
Mingliang WangSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2025A1515011463
6 · The paper itself

Abstract

Caseinolytic protease P (ClpP) is essential for maintaining mitochondrial protein homeostasis, and its activation has emerged as an attractive cancer therapeutic strategy. However,

Indexed as

Antineoplastic AgentsDrug DesignEndopeptidase ClpImidazolesPiperidinesApoptosisCell Line, TumorCell ProliferationHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsEndopeptidase ClpImidazolesimidazolonepiperidinePiperidinesanti-tumorClpPsmall molecule activatorstructure-guided drug design

Identifiers

PMID42653996
PMCPMC13515953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.