The Arylation of α,β-Unsaturated Carbonyl Compounds by Arenediazonium Salts-A Synthetic Route to Precursors of Substituted 2-Mercaptothiazoles.

Mary Y Ostapiuk, Oksana V Barabash, Mykola D Obushak, Mykola Kravets, Andreas Schmidt, Yurii V Ostapiuk

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Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Mary Y OstapiukDepartment of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya Str. 6, 79005 Lviv, Ukraine.

Oksana V BarabashDepartment of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya Str. 6, 79005 Lviv, Ukraine.

Mykola D ObushakDepartment of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya Str. 6, 79005 Lviv, Ukraine.ORCID 0000-0001-8146-9529

Mykola KravetsInstitute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-7751-3643

Andreas SchmidtInstitute of Organic Chemistry, Clausthal University of Technology, Leibnizstrasse 6, D-38678 Clausthal-Zellerfeld, Germany.ORCID 0000-0002-6160-6108

Yurii V OstapiukDepartment of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya Str. 6, 79005 Lviv, Ukraine.

Funding

National Research Foundation of Ukraine 2025.07/0221

6 · The paper itself

Abstract

This paper presents the first examples of the use of arylation products of α,β-unsaturated carbonyl compounds under Meerwein reaction conditions for the synthesis of substituted 2-mercaptothiazoles. The method described here yields α-thiocyanatocarbonyl building blocks, which subsequently enable cyclization reactions with thiourea or mercaptoacetamides to synthesize the title compounds. In this way, 5-arylmethyl-2-mercaptothiazoles substituted at the 4-position and their S-substituted derivatives can be prepared very efficiently.

Indexed as

arenediazonium saltsMeerwein reactionthiazole-2-thiolsα-thiocyanatocarbonyl compounds

Identifiers

PMID42653987

DOI10.3390/molecules31162908

PMCPMC13515875

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