Exploring the Suitability of High-Performance Thin-Layer Chromatography for the Analysis of Drug Admixtures in Total Parenteral Nutrition Using Caffeine, Ibuprofen and Midazolam as Model Drugs.

K M Yasif Kayes Sikdar, Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, Marcus Femia, Cornelia Locher

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Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

K M Yasif Kayes SikdarDepartment of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-4958-2745

Md Khairul IslamDepartment of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-9333-6536

Tomislav SostaricDepartment of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-0154-4179

Lee Yong LimDepartment of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-7307-0742

Marcus FemiaPharmacy Department, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, WA 6008, Australia.

Cornelia LocherDepartment of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-8773-3036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Total parenteral nutrition (TPN) is a nutritional therapy in children when oral or enteral feeding is not possible, fails to meet nutritional requirements or is contraindicated due to underlying clinical conditions. There are many cases where children who are given one or more than one intravenous medication also need TPN. In order to minimise vein access, these medications are commonly administered via a Y-site IV connection where they admix with TPN, implying a need for compatibility studies before admixing the medication into the nutritional fluid. In this study, previously developed and validated HPTLC methods were verified for their suitability to evaluate the concentrations of three commonly used medications in neonatal intensive care units (NICUs), namely caffeine citrate, ibuprofen arginine, and midazolam hydrochloride. Silica gel 60 F254 HPTLC plates were used as the stationary phase, and acetone: toluene: chloroform (4:3:3,

Indexed as

CaffeineIbuprofenMidazolamParenteral Nutrition, TotalChromatography, Thin LayerCitratesHumansCaffeinecaffeine citrateCitratesIbuprofenMidazolamchemical compatibilitydrug admixingHPTLCtotal parenteral nutrition (TPN)

Identifiers

PMID42653984

DOI10.3390/molecules31162904

PMCPMC13515485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.