Pungenin Promotes Hair Growth in Mouse Models of Androgenic Alopecia Through Transcriptional Regulation of the PI3K/AKT/mTOR Axis.

Wencai Zhai, Jun Yang, Lei Zhang, Zikai Lin, Wendi Xie, Shaohong Wen, Gang Li

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wencai ZhaiCollege of Life Sciences, Yantai University, Yantai 264003, China.

Jun YangCollege of Life Sciences, Yantai University, Yantai 264003, China.

Lei ZhangCollege of Life Sciences, Yantai University, Yantai 264003, China.

Zikai LinCollege of Life Sciences, Yantai University, Yantai 264003, China.ORCID 0009-0008-9313-3166

Wendi XieCollege of Life Sciences, Yantai University, Yantai 264003, China.

Shaohong WenCollege of Life Sciences, Yantai University, Yantai 264003, China.

Gang LiCollege of Life Sciences, Yantai University, Yantai 264003, China.ORCID 0000-0002-5743-0963

Funding

Science and Technology Department of Qinghai Province 2024-SF-145

6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is the most common form of hair loss, characterized by the progressive miniaturization of hair follicles driven by dihydrotestosterone (DHT)-mediated androgen receptor signaling. Current pharmacotherapies remain limited in efficacy and are often associated with undesirable side effects. Pungenin, a phenolic glucoside isolated from

Indexed as

AlopeciaGene Expression RegulationHairPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesAnimalsDihydrotestosteroneDisease Models, AnimalHair FollicleMaleMiceDihydrotestosteronemTOR protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasesandrogenetic alopeciahair follicle cellsPI3K/AKT/FoxO/mTOR signalingPicea wilsonii Mastpungenin

Identifiers

PMID42653946

DOI10.3390/molecules31162864

PMCPMC13515395

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.