Sulfur(VI) Fluoride Exchange Chemistry in Polymer Functionalization: Post-Polymerization Modification, Interface Engineering, and Biopolymer Conjugation.

Xiaohe Zhang, Pengrui Du, Lingxia Chen, Minlong Wang, Xiangyu Liu, Ruoyan Yang, Jie An

Abstract readReview

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Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Xiaohe ZhangDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Pengrui DuDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Lingxia ChenDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Minlong WangDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-8631-3523

Xiangyu LiuDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Ruoyan YangFaculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.

Jie AnDepartment of Nutrition and Health, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-1521-009X

Funding

Chinese Universities Scientific Fund 2025TC119

6 · The paper itself

Abstract

Sulfur(VI) fluoride exchange (SuFEx) chemistry is a powerful click reaction for modular synthesis, distinguished by high chemoselectivity, broad functional-group tolerance and the formation of robust sulfur(VI)-based linkages. These attributes are particularly valuable for polymer functionalization, as S(VI)-F handles on either the polymer or the modifier enable covalent coupling under controlled conditions. This review spans SuFEx-mediated post-polymerization modification and architectural control of synthetic polymers, surface, interfacial and porous-material functionalization, and SuFEx-based conjugation and covalent capture in natural and sequence-defined biopolymers. Across these contexts, we compare the advantages, supporting mechanistic and analytical evidence, current limitations and future opportunities of SuFEx-enabled polymer functionalization.

Indexed as

biopolymer conjugationcovalent capturepost-polymerization modificationsulfur(VI) fluoride exchangesurface chemistry

Identifiers

PMID42653914

DOI10.3390/molecules31162832

PMCPMC13515372

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