Evidence map›Paper›PMID 42653903›Full record

ArticleMolecules (Basel, Switzerland)2026

Corosolic Acid Induces Endothelium-Dependent Vasorelaxation in Isolated Rat Aortic Rings.

Fangying Chen, Wan Yin Tew, Ming Thong Ong, Mun Fei Yam

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fangying ChenInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0003-3134-6779
Wan Yin TewDepartment of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0001-7259-4010
Ming Thong OngInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0002-6639-9718
Mun Fei YamDepartment of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0003-4138-711X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of Corosolic acid (CA) on vascular tone and the possible mecha-nisms involved remain unclear. The SPF-grade male Sprague-Dawley rats (Animal Ethics Approval ID: USM/IACUC/2025/(155)(1406)) were used. The vasorelaxant effects of CA were evaluated in endothelium-intact and endothelium-denuded rings precontracted with phenylephrine (PE), and in endothelium-intact rings precontracted with KCl. Possible mechanisms were examined using L-NAME, ODQ, methylene blue, indomethacin, atropine, propranolol, and potassium channel blockers (glibenclamide, TEA, BaCl

Indexed as

AortaEndothelium, VascularVasodilationVasodilator AgentsAnimalsCalciumCalcium ChannelsMalePotassium Channel BlockersRatsRats, Sprague-DawleyCalciumCalcium ChannelsPotassium Channel BlockersVasodilator Agentscalcium signallingCorosolic acidendotheliumisolated aortic ringpotassium channelsvasorelaxation

Identifiers

PMID42653903
PMCPMC13515119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.