Evidence map›Paper›PMID 42653870›Full record

ArticleMolecules (Basel, Switzerland)2026

Melittin- and Apamin-Standardized Bee Venom: UHPLC-ESI-MS Characterization, Antibacterial Activity, and Apoptosis Induction in Human Keratinocytes.

Anna Kurek-Górecka, Małgorzata Kłósek, Dagmara Jaworska, Anna Mertas, Radosław Balwierz, Sebastian Granica, Mirosław Szczepański, Katarzyna Piszczatowska, Sevgi Kolayli, Zenon P Czuba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna Kurek-GóreckaDepartment of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.ORCID 0000-0002-2006-6715
Małgorzata KłósekDepartment of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.ORCID 0000-0002-9266-2292
Dagmara JaworskaDepartment of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.ORCID 0000-0002-6796-3034
Anna MertasDepartment of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.ORCID 0000-0003-0796-8818
Radosław BalwierzInstitute of Chemistry, University of Opole, Oleska 48, 45-052 Opole, Poland.ORCID 0000-0002-6173-2702
Sebastian GranicaDepartment of Pharmaceutical Biology, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.ORCID 0000-0002-1876-1321
Mirosław SzczepańskiDepartment of Biochemistry, Medical University of Warsaw, 02-091 Warsaw, Poland.ORCID 0000-0002-5206-137X
Katarzyna PiszczatowskaDepartment of Biochemistry, Medical University of Warsaw, 02-091 Warsaw, Poland.
Sevgi KolayliDepartment of Chemistry, Faculty of Science, Karadeniz Technical University, 61080 Trabzon, Türkiye.ORCID 0000-0003-0437-6139
Zenon P CzubaDepartment of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.ORCID 0000-0001-8216-4495

Funding

Medical University of Silesia BNW-1-052/K/6/O
6 · The paper itself

Abstract

Bee venom (BV) is valued therapeutically mainly for its peptides, melittin and apamin. This study determined the dose-dependent biological activity of bee venom standardized to its melittin and apamin content by UHPLC-ESI-MS, as well as that of its principal peptides, melittin and apamin, tested at matched concentrations. Antibacterial activity was assessed as showing the minimum inhibitory and minimum bactericidal concentrations (MIC, MBC) against

Indexed as

Anti-Bacterial AgentsApaminApoptosisBee VenomsKeratinocytesMelittenAnimalsChromatography, High Pressure LiquidHumansMicrobial Sensitivity TestsSpectrometry, Mass, Electrospray IonizationStaphylococcus aureusStaphylococcus epidermidisAnti-Bacterial AgentsApaminBee VenomsMelittenantibacterial agentapaminbee venommelittinskin

Identifiers

PMID42653870
PMCPMC13515527

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.