Evidence map›Paper›PMID 42653780›Full record

ArticlePharmaceuticals (Basel, Switzerland)2026

Single-Cell RNA Sequencing Reveals T-Cell Metabolic Activation and SGPL1 as a Candidate Predictor of PD-1 Resistance in Urothelial Carcinoma.

Zheng Chao, Yuchen Mei, Hao Peng, Guowen Li, Xiaodong Hao, Yuchuan Liu, Guanglu Lyu, Zhihua Wang, Le Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zheng ChaoDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Yuchen MeiDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Hao PengDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Guowen LiDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiaodong HaoDepartment of Urology, South China Hospital, Shenzhen University, Shenzhen 518111, China.
Yuchuan LiuDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Guanglu LyuDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhihua WangDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0002-5155-1457
Le LiDepartment of Urology, Hubei Provincial Clinical Medical Research Center for Minimally Invasive Treatment of Urology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.

Funding

China Postdoctoral Science Foundation 2025M781991Hubei Provincial Natural Science Foundation innovation and Development joint Fund 2024AFD420Hubei Provincial Natural Science Foundation innovation and Development joint Fund 2025AFD347Key Project of Hubei Provincial Health Commission W]2025Z014
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

macrophage polarizationmetabolic reprogrammingPD-1 resistanceSGPL1single-cell RNA sequencingurothelial carcinoma

Identifiers

PMID42653780
PMCPMC13516509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.