Evidence map›Paper›PMID 42653573›Full record

ArticleMicromachines2026

Microfluidic Chip for High-Throughput Microstructure Detection of Precursor Particles.

Fenglin Han, Jing Wang, Jinlong Wu, Jing Yang, Hu He, Zhi Chen

Abstract read
In one paragraph

Article in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fenglin HanCollege of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.ORCID 0000-0003-4392-9752
Jing WangCollege of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Jinlong WuCollege of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Jing YangCollege of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Hu HeCollege of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.ORCID 0000-0002-4199-027X
Zhi ChenCollege of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.

Funding

National Natural Science Foundation of China 52227806Scientific Research Fund of Hunan Provincial Education Department 25A0022
6 · The paper itself

Abstract

The microstructure of ternary precursors significantly influences the electrochemical performance of ternary cathode materials and, consequently, the overall performance of lithium-ion batteries. In industrial production utilizing traditional co-precipitation methods, Scanning Electron Microscopy (SEM) is typically employed for particle detection. However, this approach is limited by offline sampling lag, poor representativeness, cumbersome sample preparation, and low efficiency, failing to achieve real-time quality feedback on production lines. To enable high-throughput particle detection, this study proposes a multi-layer PDMS chip designed for three-dimensional (3D) hydrodynamic focusing. The sheath fluid compressed the sample flow in horizontal and vertical directions, respectively, to form a flat ribbon flow passing through the detection area. High-fidelity raw images are captured for automated particle microstructure analysis. Firstly, a chemical pretreatment protocol was optimized to ensure stable precursor solution transport. Secondly, a three-layer composite microchannel featuring a sequential horizontal and vertical sheath-flow compression mechanism was designed, with its geometry optimized via Computational Fluid Dynamics (CFD) simulations. Subsequently, experimental optimizations of flow rate ratios were performed using sodium fluorescein, followed by validation with ternary precursor solutions. The results indicate that the microchannel achieves flattened monolayer focusing of randomly distributed precursor particles, compressing the sample stream height to approximately 15.44 μm, thereby maintaining the particle stream within the microscope's depth of field and analyzing particle microstructure efficiently based on a microscopic image. Moreover, it is confirmed that the focused stream dimensions are primarily governed by the flow rate ratio, allowing for a flexible increase in detection throughput by adjusting the total flow rate. Different from static offline particle analyzers, this platform captures dynamic particle morphology under continuous flow, providing real-time data to guide co-precipitation reaction adjustment.

Indexed as

hydrodynamic focusingmicrofluidic chipparticle detectionternary precursor

Identifiers

PMID42653573
PMCPMC13515249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.