Evidence map›Paper›PMID 42653500›Full record

ArticleInternational journal of molecular sciences2026

Serum Periostin as a Complementary Biomarker of Frailty in Type 2 Diabetes: A Pilot Study Using the FRAIL Scale.

Sheila González-Salvatierra, Beatriz García-Fontana, Cristina García-Fontana, Luis Martínez-Heredia, José Francisco Rojas-Pérez, María Carmen Andreo-López, Antonia García-Martín, Manuel Muñoz-Torres

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sheila González-SalvatierraEndocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-6413-7001
Beatriz García-FontanaEndocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-4134-5561
Cristina García-FontanaEndocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-9328-6022
Luis Martínez-HerediaCIBER of Frailty and Healthy Aging (CIBERFES), Centro de Investigación Biomédica en Red (CIBER), Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-9330-8108
José Francisco Rojas-PérezDiaverum Málaga, 29002 Málaga, Spain.ORCID 0009-0003-1393-9885
María Carmen Andreo-LópezEndocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0009-0002-7452-4387
Antonia García-MartínEndocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-5104-9942
Manuel Muñoz-TorresEndocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-9645-3260

Funding

Instituto de Salud Carlos III PI18-01235Instituto de Salud Carlos III PI22/00726
6 · The paper itself

Abstract

Frailty is a multidimensional syndrome of reduced physiological reserve that is particularly prevalent in individuals with type 2 diabetes. Identifying objective biochemical markers to complement clinical screening tools, such as the FRAIL scale, is an increasingly important unmet need. Periostin, a matricellular protein involved in tissue remodeling, bone metabolism, and chronic complications of diabetes, has emerged as a potential candidate. In this cross-sectional study of 137 adults with type 2 diabetes (65 ± 8 years), participants were classified as robust, pre-frail, or frail according to FRAIL scores. Frailty correlated positively with age (

Indexed as

BiomarkersCell Adhesion MoleculesDiabetes Mellitus, Type 2FrailtyPeriostinAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPilot ProjectsBiomarkersCell Adhesion MoleculesPeriostinPOSTN protein, humanbiomarkerFRAIL scalefrailtyperiostintype 2 diabetes

Identifiers

PMID42653500
PMCPMC13513333

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.