In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Maurizio BruschiLaboratory of Molecular Nephrology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0001-6036-1500 Simona GranataDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-3740-7598 Silvia LaiNephrology, Dialysis and Transplantation Unit, Department of Translational and Precision Medicine, Sapienza University of Rome-Policlinico Umberto I, 00185 Rome, Italy.ORCID 0000-0002-7199-2954 Valentina PistolesiNephrology, Dialysis and Transplantation Unit, Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0002-9720-9462 Laura BarberioDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Rossana D'AgostinoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Francesca SoraceDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Francesca GiordanoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-7621-1969 Paola PontrelliNephrology, Dialysis and Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-7654-8318 Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, 70124 Bari, Italy.
Lida TartaglioneNephrology, Dialysis and Transplantation Unit, Policlinico Umberto I, 00161 Rome, Italy.
Giovanni CandianoLaboratory of Molecular Nephrology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, 16147 Genoa, Italy.
Sonia SpinelliLaboratory of Molecular Nephrology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0001-9847-4308 Chiara LavarelloCore Facility for Omics Sciences, IRCCS Istituto Giannina, 16147 Genoa, Italy.
Edoardo La PortaNephrology, Dialysis and Transplantation Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, 16147 Genoa, Italy.
Michele ProvenzanoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-2168-702X Gianluigi ZazaNephrology, Dialysis and Transplantation Unit, Department of Translational and Precision Medicine, Sapienza University of Rome-Policlinico Umberto I, 00185 Rome, Italy.ORCID 0000-0002-6004-6196 Funding
Ministero della Salute PNRR-MR1-2022-12375880Ministero dell'università e della ricerca 2022FH7889
6 · The paper itselfAbstract
Although the clinical differences between hemodialysis (HD) and peritoneal dialysis (PD) are well established, the specific biological mechanisms underlying these differences remain incompletely understood. We performed untargeted proteomic and transcriptomic analyses of peripheral blood mononuclear cells (PBMCs) from healthy controls (CTRs) and patients with chronic kidney disease undergoing HD or PD. Key findings were validated in an independent cohort using standardized biomolecular techniques. Bioinformatic analysis identified 36 differentially expressed proteins and 19 transcripts between HD and PD according to the predefined FDR-adjusted significance threshold. Functional enrichment analysis revealed that these factors were primarily involved in cellular senescence, aging, and stress-response pathways. Among the identified molecules, interferon regulatory factor 8 (IRF8) was the only factor consistently upregulated in HD compared with PD in both omics analyses. This finding was confirmed by ELISA in an independent cohort (
Indexed as
Leukocytes, MononuclearPeritoneal DialysisRenal DialysisRenal Insufficiency, ChronicAgedCellular SenescenceFemaleGene Expression ProfilingHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsMaleMiddle AgedMultiomicsProteomeProteomicsInterferon Regulatory Factor-8Interferon Regulatory FactorsProteomecellular senescencechronic kidney diseasehemodialysisIRF8peritoneal dialysisproteomics
Identifiers
PMID42653471
PMCPMC13512927
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