NMR Structural Elucidation of Mitoxantrone-Gonadotropin-Releasing Hormone (GnRH) Conjugates Implicated in Hormone-Dependent Cancer.

Georgia Biniari, Haralambos Tzoupis, Uroš Javornik, Nikitas Georgiou, Georgios Liapakis, Thomas Mavromoustakos, Theodore Tselios, Carmen Simal

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

8 authors.

Georgia BiniariDepartment of Chemistry, University of Patras, 26504 Rion Patras, Greece.ORCID 0009-0000-5789-8884

Haralambos TzoupisDepartment of Chemistry, University of Patras, 26504 Rion Patras, Greece.ORCID 0000-0002-1534-2762

Uroš JavornikSlovenian NMR Centre, National Institute of Chemistry, SI-1001 Ljubljana, Slovenia.ORCID 0000-0002-7959-6681

Nikitas GeorgiouDepartment of Chemistry, National and Kapodistrian University of Athens, 10679 Athens, Greece.ORCID 0000-0002-3226-7434

Georgios LiapakisDepartment of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-2423-3135

Thomas MavromoustakosDepartment of Chemistry, National and Kapodistrian University of Athens, 10679 Athens, Greece.ORCID 0000-0001-5309-992X

Theodore TseliosDepartment of Chemistry, University of Patras, 26504 Rion Patras, Greece.ORCID 0000-0002-1310-0591

Carmen SimalDepartment of Chemistry, University of Patras, 26504 Rion Patras, Greece.ORCID 0000-0002-7096-4281

Funding

Greek National Funds T2EDK 02056

6 · The paper itself

Abstract

Gonadotropin-Releasing Hormone receptors (GnRHRs) are overexpressed in several hormone-dependent malignancies, making them attractive molecular targets for selective anticancer drug delivery. Peptide-drug conjugates (PDCs) are a promising therapy for cancer and autoimmune diseases with high specificity and reduced toxicity. In this study, the three-dimensional structures of two previously synthesized mitoxantrone-GnRH conjugates, con3 and con7, were elucidated using high-resolution NMR spectroscopy in combination with molecular dynamics (MD) simulations. Complete

Indexed as

Antineoplastic AgentsGonadotropin-Releasing HormoneMitoxantroneNeoplasmsHumansMagnetic Resonance SpectroscopyMolecular Dynamics SimulationReceptors, LHRHAntineoplastic AgentsGonadotropin-Releasing HormoneMitoxantroneReceptors, LHRHGnRH receptorGonadotropin Releasing Hormone (GnRH)MD simulationsmitoxantroneNMR spectroscopypeptide drug conjugates (PDCs)structure elucidationtargeted cancer therapy

Identifiers

PMID42653438

DOI10.3390/ijms27167437

PMCPMC13513673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.