ArticleInternational journal of molecular sciences2026
Sarcopenia and Frailty in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): The Impact of Steroid Hormones.
Triada Bali, Jennifer Lai, Niki G Mourelatou, Aristi Saridaki, Sofia Tsitsou, Magdalini Adamantou, Aikaterini Kamiliou, Christos Chologitas, Margarita Sarri, Dimitra Pavlopoulou and 3 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
Triada BaliFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.
Jennifer LaiDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California-San Francisco, 400 Parnassus Avenue, Floor 7, San Francisco, CA 94143, USA.
Niki G MourelatouFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.
Aristi SaridakiFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0009-0006-8240-6865 Sofia TsitsouFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0000-0002-0045-0461 Magdalini AdamantouFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0009-0000-3306-050X Aikaterini KamiliouFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0009-0009-7254-4617 Christos ChologitasFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.
Margarita SarriFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.
Dimitra PavlopoulouFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.
Evangelos LiberopoulosFirst Department of Propaedeutic and Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0000-0002-7162-3323 Anna AngelousiFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0000-0003-0906-3617 Evangelos CholongitasFirst Department of Internal Medicine, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Agiou Thoma 17, 11526 Athens, Greece.ORCID 0000-0002-3645-582X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to sarcopenia and frailty, but data on white populations remain limited. This study evaluated sarcopenia, physical performance and steroid hormone associations with frailty in European MASLD patients. A cross-sectional study included 245 white MASLD patients. Clinical, biochemical, hormonal and elastography data were collected. Sarcopenia was assessed using dual-energy X-ray absorptiometry alongside mid-arm muscle circumference (MAMC), while physical performance was assessed using the liver frailty index (LFI) and the short physical performance battery (SPPB). Mean age was 56.2 years, 45.7% were male, and median liver stiffness was 5.2 kPa; 76.3% and 33.9% of patients had low MAMC and Appendicular Lean Mass Index, while 13.5% had abnormal SPPB and 16% were frail (i.e., LFI > 4.4). Poor physical performance was linked to lower dehydroepiandrosterone sulfate (DHEAS) levels using both LFI (OR: 0.98, 95% C.I.: 0.96-0.99,
Indexed as
Fatty LiverFrailtyNon-alcoholic Fatty Liver DiseaseSarcopeniaAbsorptiometry, PhotonAgedCross-Sectional StudiesDehydroepiandrosterone SulfateFemaleHumansMaleMiddle AgedDehydroepiandrosterone Sulfatedehydroepiandrosterone sulfate (DHEAS)dual-energy X-ray absorptiometry (DEXA)liver frailty index (LFI)metabolic dysfunction- associated steatotic liver disease (MASLD)physical performancesarcopeniashort physical performance battery (SPPB)
Identifiers
PMID42653433
PMCPMC13512960
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