Evidence map›Paper›PMID 42653386›Full record

ReviewInternational journal of molecular sciences2026

Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.

Bianca G Obadic, Jonathan N Katsukunya, Bianca Davidson, Erika S W Jones, Bridget Hodkinson, Robert Freercks, Collet Dandara, Khuthala Mnika

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianca G ObadicDivision of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
Jonathan N KatsukunyaDivision of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
Bianca DavidsonPlatform for Pharmacogenomics Research and Translation, South African Medical Research Council, Cape Town 7925, South Africa.
Erika S W JonesPlatform for Pharmacogenomics Research and Translation, South African Medical Research Council, Cape Town 7925, South Africa.ORCID 0000-0002-3569-3498
Bridget HodkinsonRheumatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Robert FreercksDepartment of Medicine, School of Medicine, Faculty of Health Sciences, Nelson Mandela University, Gqeberha 6031, South Africa.ORCID 0000-0002-7939-1352
Collet DandaraDivision of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0002-5925-4895
Khuthala MnikaDivision of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0002-8461-1372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic component, and lupus nephritis (LN) represents one of its most common and severe organ-specific manifestations. This review synthesises current evidence on the genetic architecture of SLE and LN, with a particular focus on identifying shared and distinct genetic susceptibility loci and highlighting knowledge and data gaps in highly burdened African populations. Across studies, most risk loci, including

Indexed as

Genetic Predisposition to DiseaseLupus Erythematosus, SystemicLupus NephritisAfricaGenome-Wide Association StudyGenomicsHumansAfricaautoimmune diseasegeneticslupus nephritissystemic lupus erythematosus

Identifiers

PMID42653386
PMCPMC13513728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.