Evidence map›Paper›PMID 42653374›Full record

ArticleInternational journal of molecular sciences2026

Dynamic NFIX Promoter Usage Shapes Stem and Committed Myogenic States.

Gabriele Rovetta, Giulia Ferrari, Mirko Ronzio, Alberto Gallo, Raffaele Epis, Chiara Bonfanti, Diletta Dolfini, Giorgia Careccia, Graziella Messina

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriele RovettaDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0009-0005-2628-6865
Giulia FerrariDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0009-0002-6410-6587
Mirko RonzioDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-4699-4405
Alberto GalloDepartment of Biosciences, University of Milan, 20133 Milan, Italy.
Raffaele EpisDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0009-0008-8305-7788
Chiara BonfantiDepartment of Biosciences, University of Milan, 20133 Milan, Italy.
Diletta DolfiniDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-5346-6096
Giorgia CarecciaDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-4049-5186
Graziella MessinaDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-8189-0727

Funding

Telethon Foundation GMR25T2007University of Milan PSR2025_DIP_002
6 · The paper itself

Abstract

Skeletal muscle development and regeneration rely on coordinated transcriptional programs controlled by muscle stem cells and their progeny. Nuclear Factor I X (NFIX) plays essential roles in fetal myogenesis and adult muscle regeneration. However, the mechanisms regulating its transcription and isoform expression remain unclear. Here, integrating multi-omics analyses with in vitro functional assays, we define the transcriptional and epigenetic landscape controlling Nfix expression during skeletal muscle development and regeneration. We show that

Indexed as

Muscle DevelopmentNFI Transcription FactorsPromoter Regions, GeneticStem CellsAnimalsCell DifferentiationDNA MethylationEpigenesis, GeneticGene Expression Regulation, DevelopmentalMiceMuscle, SkeletalMyoblastsProtein IsoformsRegenerationNFI Transcription FactorsNfix protein, mouseProtein Isoformsalternative promotersepigenetic regulationmuscle regenerationmyogenesisNFIXsatellite cellsskeletal muscletranscript isoforms

Identifiers

PMID42653374
PMCPMC13513291

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.