Evidence map›Paper›PMID 42653335›Full record

Observational studyInternational journal of molecular sciences2026

Early Donor-Derived Cell-Free DNA Kinetics After Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Preliminary Observational Study.

Patryk Wawrzonkowski, Kornelia Gajek, Weronika Smulska, Katarzyna Grabka, Karolina Marek Bukowiec, Magdalena Kuriata-Kordek, Patryk Jerzak, Adrian Domagalski, Marek Ussowicz, Mirosław Banasik

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patryk WawrzonkowskiDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.ORCID 0000-0002-5471-2498
Kornelia GajekUniversity Clinical Hospital in Wroclaw, Borowska 213, 50-556 Wroclaw, Poland.ORCID 0000-0003-0073-7769
Weronika SmulskaDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.ORCID 0009-0005-5539-9949
Katarzyna GrabkaDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.
Karolina Marek BukowiecDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.
Magdalena Kuriata-KordekDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.ORCID 0000-0002-2817-3689
Patryk JerzakDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.ORCID 0000-0001-9004-184X
Adrian DomagalskiDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.
Marek UssowiczUniversity Clinical Hospital in Wroclaw, Borowska 213, 50-556 Wroclaw, Poland.ORCID 0000-0001-5725-4835
Mirosław BanasikDepartment of Nephrology, Transplantation Medicine and Internal Diseases, Institute of Internal Diseases, Wroclaw Medical University, 50-551 Wroclaw, Poland.ORCID 0000-0002-0588-1551

Funding

National Science Centre MINI.C200.21.008Wroclaw Medical University no. SUBZ.A500.25.019
6 · The paper itself

Abstract

Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker of kidney allograft injury. Elevated dd-cfDNA has been associated with acute rejection, particularly antibody-mediated rejection; however, dd-cfDNA reflects graft-derived tissue injury rather than a specific alloimmune mechanism. Its interpretation may therefore be challenging in conditions characterized by endothelial and microvascular injury, such as atypical hemolytic uremic syndrome (aHUS). This retrospective observational study included 14 kidney transplant recipients who underwent their first kidney transplantation at Wroclaw Medical University between April and December 2022. Twelve recipients without aHUS and two recipients with aHUS were assessed at day 7 (D7), day 14 (D14), month 1 (M1), and month 2 (M2). Protocol biopsies were not systematically performed. In recipients without aHUS, median %dd-cfDNA declined from 0.72% (range, 0.26-2.33%) at D7 to 0.12% (range, 0.05-0.34%) at M2. In the two recipients with aHUS, values remained near or above 1% through M1 and declined at M2. No donor-specific antibodies against human leukocyte antigens (HLA) or clinically documented rejection occurred. Exploratory analyses did not identify a statistically significant association between %dd-cfDNA and serum creatinine (Spearman rho = 0.09,

Indexed as

Atypical Hemolytic Uremic SyndromeCell-Free Nucleic AcidsKidney TransplantationTissue DonorsAdultBiomarkersFemaleGraft RejectionHumansKineticsMaleMiddle AgedRetrospective StudiesBiomarkersCell-Free Nucleic AcidsaHUSatypical hemolytic uremic syndromecomplementdd-cfDNAdonor-derived cell-free DNAdonor-specific antibodieskidney transplantationrejectionthrombotic microangiopathy

Identifiers

PMID42653335
PMCPMC13513804

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.