Pharmacogenomic-Guided Prescribing for Treatment-Resistant Mental Health Conditions in Australian Primary Care: A Single-GP Practice Retrospective Observation of 29 Patients.

Cristina Beer, Fiona Rae, Mikayla Watt, Annalese Semmler, Joanne Voisey

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cristina BeerCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.

Fiona RaeCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.ORCID 0009-0002-9276-0076

Mikayla WattDr. Cris Medical Services, Robina, QLD 4226, Australia.

Annalese SemmlerSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.ORCID 0000-0002-2084-4986

Joanne VoiseyCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.ORCID 0000-0001-6645-6164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment-resistant mental health conditions are common in primary care and challenging for clinicians. Trial-and-error prescribing can prolong morbidity and increase adverse drug reactions (ADRs). Pharmacogenomic (PGx) testing enables individualised prescribing by identifying gene-drug interactions affecting psychotropic response. Thirty adults with treatment-resistant mental health conditions underwent PGx testing using a commercial panel (one lost to follow-up [

Indexed as

Mental DisordersPharmacogeneticsPsychotropic DrugsAdultAustraliaCytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6FemaleGenotypeHumansMaleMiddle AgedPharmacogenomic TestingPrecision MedicinePrimary Health CareRetrospective StudiesCYP2C19 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6Psychotropic Drugscytochrome P-450 enzyme systempharmacogeneticsprecision medicineprimary health carepsychotropic drugs

Identifiers

PMID42653333

DOI10.3390/ijms27167329

PMCPMC13513532

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.