ArticleInternational journal of molecular sciences2026
CRISPR/Cas9-Mediated Disruption of Duplicated Sizzled Genes Induces Twin-Tail-like Caudal Bifurcation in Goldfish (
Huijuan Li, Xiaoying Zhang, Xiaowen Wang, Rong Zhang, Lili Liu, Lixin Sun, Zhigang Yao, Hua Zhu
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Huijuan LiBeijing Key Laboratory of Fishery Biotechnology, Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.ORCID 0009-0009-8875-8994 Xiaoying ZhangLaboratory of Molecular Physiology, Department of Zoology, Kiel University, 24098 Kiel, Germany.
Xiaowen WangBeijing Key Laboratory of Fishery Biotechnology, Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Rong ZhangBeijing Key Laboratory of Fishery Biotechnology, Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Lili LiuBeijing Key Laboratory of Fishery Biotechnology, Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.ORCID 0000-0001-8608-6471 Lixin SunFisheries College, Jimei University, Xiamen 361021, China.
Zhigang YaoBeijing Key Laboratory of Fishery Biotechnology, Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Hua ZhuBeijing Key Laboratory of Fishery Biotechnology, Fisheries Science Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Funding
Beijing Academy of Agricultural and Forestry Sciences GHPT2026-16Beijing Academy of Agricultural and Forestry Sciences KJCX20230216Beijing Academy of Agricultural and Forestry Sciences KJCX20261411Beijing Academy of Agricultural and Forestry Sciences PT2025-20China International Science and Technology Cooperation GHPT2026-06National Natural Science Foundation of China 32403015National Natural Science Foundation of China 6262009Rural Development Institute NY2401170024
6 · The paper itselfAbstract
The twin-tail phenotype of goldfish represents a striking domestication-associated remodeling of the vertebrate caudal axial system and is classically linked to disruption of Chordin/BMP-mediated dorsal-ventral patterning. Although previous knockdown studies implicated sizzled (
Indexed as
CRISPR-Cas SystemsFish ProteinsGoldfishAnimalsBody PatterningGene Expression Regulation, DevelopmentalGlycoproteinsIntercellular Signaling Peptides and ProteinschordinFish ProteinsGlycoproteinsIntercellular Signaling Peptides and ProteinsCRISPR/Cas9goldfishsizzledtwin-tail phenotype
Identifiers
PMID42653322
PMCPMC13513690
What OpenQuestion holds
Textmetadata
Read underepoch 390