Evidence map›Paper›PMID 42653314›Full record

ArticleInternational journal of molecular sciences2026

Integrin α7-Driven Senescence-Associated Follicular Helper T Cell Adhesion Induces Tertiary Lymphoid Structures in Nishiura Mice.

Hiroshi Nishiura, Naoto Azuma, Kiyoshi Matsui, Teppei Hashimoto, Yoshiro Naito, Wenting Chen, Mai Imasaka, Masaki Ohmuraya

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hiroshi NishiuraDepartment of Genetics, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.ORCID 0000-0002-5741-0276
Naoto AzumaDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.ORCID 0000-0002-4773-1535
Kiyoshi MatsuiDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Teppei HashimotoDivision of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Yoshiro NaitoDepartment of Cardiovascular and Renal Medicine, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.ORCID 0000-0002-9859-7153
Wenting ChenDepartment of Genetics, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Mai ImasakaDepartment of Genetics, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Masaki OhmurayaDepartment of Genetics, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.

Funding

Hyogo Medical University Innovation Challenge Program 2025Japan Agency for Medical Research and Development DNW-19017
6 · The paper itself

Abstract

Senescence-associated follicular helper T (SA-Tfh) cells contribute to tertiary lymphoid structure (TLS) formation in autoimmune diseases, yet the mechanisms guiding their localization to glandular niches remain unclear. In the Nishiura (NI) Sjögren's disease (SjD) mouse model, we demonstrated that mouse SA-Tfh (mSA-Tfh; CD4

Indexed as

Cellular SenescenceIntegrin alpha ChainsSjogren's SyndromeTertiary Lymphoid StructuresT Follicular Helper CellsAnimalsAntigens, CDCell AdhesionDisease Models, AnimalFemaleLamininMiceMice, Inbred C57BLSubmandibular GlandAntigens, CDintegrin alpha7Integrin alpha ChainsLamininintegrin α7laminin α4Nishiura micesenescence-associated follicular helper T cellsSjögren’s diseasetertiary lymphoid structure

Identifiers

PMID42653314
PMCPMC13513366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.