Evidence map›Paper›PMID 42653287›Full record

ReviewInternational journal of molecular sciences2026

The Kallikrein-Kinin System: Proteolytic Orchestrators of Tissue Barrier Disruption in Inflammation and Cancer.

Areli Cárdenas-Oyarzo, Carlos D Figueroa, Ricardo Huilcamán, Larissa Turones, Sergio Martínez-Huenchullán, Pamela Ehrenfeld

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Areli Cárdenas-OyarzoCentro Integrativo de Biología y Química Aplicada (CIBQA), Facultad de Ciencias de la Salud, Universidad Bernardo OHiggins, General Gana 1702, Santiago 8370854, Chile.
Carlos D FigueroaLaboratory of Cellular Pathology, Institute of Anatomy, Histology & Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile.
Ricardo HuilcamánSchool of Medical Technology, Faculty of Health Sciences, Universidad Bernardo O'Higgins, Santiago 8370854, Chile.
Larissa TuronesLaboratory of Cellular Pathology, Institute of Anatomy, Histology & Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile.ORCID 0000-0003-4646-5682
Sergio Martínez-HuenchullánSchool of Physical Therapy, Universidad San Sebastián, Valdivia 5090000, Chile.ORCID 0000-0002-6336-5571
Pamela EhrenfeldLaboratory of Cellular Pathology, Institute of Anatomy, Histology & Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile.ORCID 0000-0002-2519-7570

Funding

Austral University of Chile the Graduate School of the Faculty of Medicine of the Austral University of ChileAustral University of Chile Vice-Rectorate of Development, Innovation and Artistic Creation (VIDCA)National Agency for Research and Development 11220657 A.C-O, .; #1201635 P.E.; Fondecyt #11200391 S.M; Fondecyt #3250659 L.C.T
6 · The paper itself

Abstract

The kallikrein-kinin system (KKS) and the kallikrein-related peptidase (KLK) family are interconnected proteolytic networks that regulate inflammatory signaling, vascular permeability, extracellular matrix remodeling, and tissue barrier dynamics. Beyond their classical vasoactive and inflammatory functions, accumulating evidence indicates that kinin peptides, including bradykinin, Lys-bradykinin, and their des-Arg

Indexed as

InflammationKallikrein-Kinin SystemNeoplasmsAnimalsHumansKallikreinsProteolysisSignal TransductionKallikreinscancercell adhesioninflammationkallikrein-related peptidaseskinin peptideskinin receptors

Identifiers

PMID42653287
PMCPMC13513620

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.