Evidence map›Paper›PMID 42653278›Full record

Observational studyInternational journal of molecular sciences2026

Longitudinal Kinetics of Cerebrospinal Fluid and Serum S100B in Patients with Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Małgorzata Burzyńska, Adrianna Lebiedzińska, Jarosław Kędziora, Katarzyna Smarzewska, Anna Lemańska-Perek, Maciej Miś, Agnieszka Uryga, Barbara Adamik, Waldemar Goździk

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Małgorzata BurzyńskaClinical Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0003-2318-7130
Adrianna LebiedzińskaClinical Department of Anesthesiology and Intensive Therapy, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, Poland.ORCID 0009-0002-1177-9366
Jarosław KędzioraClinical Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0001-5682-1092
Katarzyna SmarzewskaClinical Department of Neurosurgery, University Centre for Neurology and Neurosurgery, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, Poland.ORCID 0000-0002-3933-9277
Anna Lemańska-PerekDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-369 Wroclaw, Poland.
Maciej MiśClinical Department of Neurosurgery, University Centre for Neurology and Neurosurgery, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, Poland.
Agnieszka UrygaDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland.ORCID 0000-0001-8183-7643
Barbara AdamikClinical Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0002-0541-841X
Waldemar GoździkClinical Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.

Funding

the Research Committee of the Medical University of Wroclaw SUBK.A170.26.011
6 · The paper itself

Abstract

S100 calcium-binding protein B (S100B) has been proposed as a biomarker of brain injury after aneurysmal subarachnoid hemorrhage (aSAH), although the clinical utility of serial measurements remains uncertain. This prospective observational study investigated whether longitudinal serum and cerebrospinal fluid (CSF) S100B concentrations are associated with delayed cerebral ischemia (DCI), inflammatory activation, and neurological outcome. Twenty-six consecutive patients with aSAH underwent serial serum and CSF S100B measurements throughout hospitalization. Associations between S100B concentrations, DCI, disease severity, inflammatory biomarkers, and 3-month neurological outcome were analyzed. Admission serum S100B concentrations were significantly higher in patients who subsequently developed DCI (152.6 vs. 21.0 ng/L,

Indexed as

Brain IschemiaS100 Calcium Binding Protein beta SubunitSubarachnoid HemorrhageAdultAgedBiomarkersFemaleHumansKineticsLongitudinal StudiesMaleMiddle AgedProspective StudiesBiomarkersS100B protein, humanS100 Calcium Binding Protein beta Subunitaneurysmal subarachnoid hemorrhagedelayed cerebral ischemianeuroinflammationneuron-specific enolaseprotein S100B

Identifiers

PMID42653278
PMCPMC13513958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.