Evidence map›Paper›PMID 42653272›Full record

ArticleInternational journal of molecular sciences2026

LPS and β-Glucan Induce Differential Memory-like Inflammatory Responses with Enhanced Reactivity in Neonatal Neutrophils Compared to Adults.

Lisa Zagler, Laura Snaidr, Natascha Köstlin-Gille, Heidi Hildenbrand, Nadja Kliegel, David L Williams, Ricarda Will, Stefanie Dietz-Ziegler, Cahit Birdir, Christian Gille and 1 more

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lisa ZaglerDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Laura SnaidrDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Natascha Köstlin-GilleDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-3718-5507
Heidi HildenbrandDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Nadja KliegelDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
David L WilliamsDepartment of Surgery and Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
Ricarda WillDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Stefanie Dietz-ZieglerDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0009-0005-6326-6281
Cahit BirdirDepartment of Gynaecology and Obstetrics, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Christian GilleDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.
Trim LajqiDepartment of Neonatology, Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-2584-589X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils are key effectors of innate immunity. Although traditionally regarded as short-lived effector cells, recent evidence suggests they can undergo functional reprogramming after microbial stimulation, leading to trained immunity. We investigated whether lipopolysaccharide (LPS) or

Indexed as

beta-GlucansInflammationLipopolysaccharidesNeutrophilsAdultCytokinesHumansInfant, NewbornNF-kappa BReactive Oxygen SpeciesSignal TransductionTrained Immunitybeta-GlucansCytokinesLipopolysaccharidesNF-kappa BReactive Oxygen Speciesadultinflammationmemory-likemetabolismneonatesneutrophilssignaling

Identifiers

PMID42653272
PMCPMC13513832

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.