Evidence map›Paper›PMID 42653258›Full record

ArticleInternational journal of molecular sciences2026

Integrative Principal Component-QTL Mapping Identifies Genetic Modifiers of Tumor and Metabolic Traits in

Osayd Zohud, Kreem Midlej, Fuad A Iraqi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Osayd ZohudDepartment of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel-Aviv University, Tel Aviv-Yafo 6997801, Israel.ORCID 0000-0003-3530-1420
Kreem MidlejDepartment of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel-Aviv University, Tel Aviv-Yafo 6997801, Israel.ORCID 0000-0003-0144-575X
Fuad A IraqiDepartment of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel-Aviv University, Tel Aviv-Yafo 6997801, Israel.ORCID 0000-0001-5525-206X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic background strongly influences the penetrance and phenotypic expression of SMAD4-associated intestinal tumorigenesis, yet the underlying modifier loci remain poorly defined. To investigate the genetic architecture of tumor susceptibility and systemic physiology, we analyzed 260

Indexed as

Genes, ModifierIntestinal NeoplasmsQuantitative Trait LociSmad4 ProteinAnimalsChromosome MappingCollaborative Cross MiceFemaleGenetic Predisposition to DiseaseMaleMicePhenotypePrincipal Component AnalysisSmad4 ProteinSmad4 protein, mouseCollaborative Cross micegenetic modifiersintestinal tumorigenesisprincipal component analysisQTL mappingsex-specific effectsSmad4systems genetics

Identifiers

PMID42653258
PMCPMC13512919

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.