ArticleInternational journal of molecular sciences2026
Single-Cell Analysis Reveals STARD10 as a Fatty Acid Metabolism Regulator of Breast Cancer Progression via the PI3K/Akt Pathway.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Breast cancer is a highly heterogeneous malignancy in which fatty acid metabolism plays a critical yet insufficiently characterized role in tumor progression, immune evasion, and treatment resistance. To address this gap, we performed a comprehensive re-analysis of single-cell transcriptomic data from 62 breast cancer patients using the Non-negative Matrix Factorization (NMF) algorithm to delineate tumor cell subpopulations at single-cell resolution. Through Gene Set Enrichment Analysis (GSEA), we identified the tumor cell subgroup most significantly associated with fatty acid metabolism. Subsequent Slingshot trajectory analysis revealed STARD10 as a key regulatory gene in fatty acid metabolic reprogramming along tumor cell differentiation trajectories. In vitro functional experiments further validated that STARD10 plays a functional role in modulating fatty acid metabolism in breast cancer cells. These findings establish STARD10 as a novel molecular marker and potential therapeutic target in breast cancer, offering new insights into the metabolic mechanisms underlying tumor heterogeneity and disease progression.
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