ArticleInternational journal of molecular sciences2026
Laser-Generated Ultrashort Pulsed Electron Beams Induce p53-Related Alteration of DNA Repair and Cell Death Pathways in Non-Small Cell Lung Cancer Cells.
Margarita Pustovalova, Polina Pugacheva, Natalia Vorobyeva, Nelly Babayan, Anna Chigasova, Andrey Osipov, Anzhela Sargsyan, Gohar Tadevosyan, Ruzanna Grigoryan, Natalya Sarkisyan and 10 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
20 authors.
Margarita PustovalovaMoscow Center for Advanced Studies, Kulakova Str. 20, Moscow 123592, Russia.
Natalia VorobyevaState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia.
Anna ChigasovaState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia.
Andrey OsipovN.N. Semenov Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119991, Russia.ORCID 0000-0002-3120-8512 Anzhela SargsyanResearch Institute of Biology, Yerevan State University, 1 Manoogian, Yerevan 0025, Armenia.
Gohar TadevosyanInstitute of Molecular Biology NAS RA, 7 Hasratyan, Yerevan 0014, Armenia.
Ruzanna GrigoryanInstitute of Molecular Biology NAS RA, 7 Hasratyan, Yerevan 0014, Armenia.
Natalya SarkisyanInstitute of Molecular Biology NAS RA, 7 Hasratyan, Yerevan 0014, Armenia.
Yuriy FedotovState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia.ORCID 0000-0003-1552-2955 Andrey TsishnattiState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia.ORCID 0009-0004-5132-2701 Denis GuryevState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia.ORCID 0000-0003-4962-2145 Ashot VardanyanCANDLE Synchrotron Research Institute, 31 Acharyan, Yerevan 0040, Armenia.
Rouben AroutiounianResearch Institute of Biology, Yerevan State University, 1 Manoogian, Yerevan 0025, Armenia.
Galina HovhannisyanResearch Institute of Biology, Yerevan State University, 1 Manoogian, Yerevan 0025, Armenia.ORCID 0000-0002-7450-1508 Andreyan N OsipovState Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia.ORCID 0000-0001-5921-9056 Funding
Russian Science Foundation 19-14-00151State Committee of Science 24FP-3A057The Ministry of Education and Science of the Russian Federation 1024122500008-3
6 · The paper itselfAbstract
Laser-driven accelerated particle beams have significantly advanced cancer treatment by facilitating the delivery of exceptionally high dose rates of radiation to solid tumors within femto- to picosecond timescales. This investigation compared the radiobiological effectiveness of ultrashort pulsed electron beams, generated by the Advanced Research Electron Accelerator Laboratory (AREAL) accelerator, with conventional X-rays on two non-small cell lung cancer (NSCLC) cell lines: A549 (wild-type p53) and H1299 (p53-deficient). NSCLC cells were irradiated using either the AREAL accelerator (with a peak dose rate of 1.6 × 10
Indexed as
Carcinoma, Non-Small-Cell LungDNA RepairElectronsLasersLung NeoplasmsTumor Suppressor Protein p53A549 CellsApoptosisCell DeathCell Line, TumorDNA DamageHistonesHumansRadiation ToleranceX-RaysHistonesTP53 protein, humanTumor Suppressor Protein p53DNA double-strand breaksionizing radiationlaser-driven acceleratorsnon-small cell lung cancerradiotherapytranscriptomicsultrashort pulsed electron beamγH2AX
Identifiers
PMID42653220
PMCPMC13513337
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